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Changing MIC Breakpoints: Do Mechanisms Count

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Efficacy of different beta-lactams against an<br />

ESBL-producing K. pneumoniae in rat IAA model<br />

Table 2: Intra-abdominal abscess treatment outcomes<br />

Antibiotic No.<br />

rats<br />

Mean serum<br />

level ( g/ml)<br />

Log10<br />

CFU/g of<br />

abscess<br />

None 30 8.02 1.02<br />

Cefoperazone 11 13.5 4.72 7.41 0.74 a<br />

Cefoperazone-sulbactam 11 8.9 3.22 5.84 0.95 c<br />

Cefotaxime 18 17.7 8.42 7.26 1.02 a<br />

Cefpirome 11 28.3 2.06 7.80 1.18 a<br />

Ceftazidime 10 19.4 3.09 8.85 0.64 a<br />

Imipenem 19 7.1 2.08 4.99 0.97 c<br />

a P>0.05, c P

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