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Sample A: Cover Page of Thesis, Project, or Dissertation Proposal

Sample A: Cover Page of Thesis, Project, or Dissertation Proposal

Sample A: Cover Page of Thesis, Project, or Dissertation Proposal

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data. Classification is continued with the same models, using ProbeSet values from the probe<br />

cleansing methods, comparing the 325 DE BaFL ProbeSets to the auth<strong>or</strong>s’ lists.<br />

Figure 3.5: Candidate lists- Bhattacharjee predict Stearman. The genes from the <strong>or</strong>iginal auth<strong>or</strong>s’ papers<br />

proposed significant ProbeSet lists, further limited by those that met the BaFL cleansing criteria but not the<br />

Welch’s t-test significance criterion, with ProbeSet values provided by one <strong>of</strong> the three data cleansing<br />

methods: these values were used as input to the three classifier models. Here training <strong>of</strong> the model used the<br />

(modified) Bhattacharjee ProbeSet list and testing was done using the Stearman data. Each graph shows<br />

the number <strong>of</strong> the ProbeSet value-generation method on the y-axis (described below) and the cumulative<br />

AUC value on the x-axis. Each row <strong>of</strong> graphs shows outcomes f<strong>or</strong> a particular initial candidate ProbeSet<br />

list. Each column <strong>of</strong> graphs shows the results f<strong>or</strong> a particular classifier, indicated in the graph. The red line<br />

highlights the 0.9 cumulative AUC. In this case the node indicates average AUC and the bars show the<br />

standard deviation f<strong>or</strong> 100 random sampling with replacement repetitions. The final column summarizes<br />

each cleansing model’s list interpretation, across the 3 classification alg<strong>or</strong>ithms. The final row <strong>of</strong> graphs<br />

summarizes the individual alg<strong>or</strong>ithms, per cleansing methodology, across all four 4 candidate lists and<br />

follows the same col<strong>or</strong> scheme.<br />

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