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Sample A: Cover Page of Thesis, Project, or Dissertation Proposal

Sample A: Cover Page of Thesis, Project, or Dissertation Proposal

Sample A: Cover Page of Thesis, Project, or Dissertation Proposal

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cleansing methods were used to generate the ProbeSet values. The same 3 classifications<br />

alg<strong>or</strong>ithms were employed as described above.<br />

Figure 3.4: Candidate lists- Stearman predict Bhattacharjee. The genes from the <strong>or</strong>iginal auth<strong>or</strong>s’ papers<br />

proposed significant ProbeSet lists, further limited by those that met the BaFL cleansing criteria but not the<br />

Welch’s t-test significance criterion, with ProbeSet values provided by one <strong>of</strong> the three data cleansing<br />

methods: these values were used as input to the three classifier models. Each graph shows the number <strong>of</strong><br />

the ProbeSet value-generation method on the y-axis (described below) and the cumulative AUC value on<br />

the x-axis. Each row <strong>of</strong> graphs shows outcomes f<strong>or</strong> a particular initial candidate ProbeSet list. Each column<br />

<strong>of</strong> graphs shows the results f<strong>or</strong> a particular classifier, indicated in the graph. The red line highlights the 0.9<br />

cumulative AUC. In this case the node indicates average AUC and the bars show the standard deviation f<strong>or</strong><br />

100 random sampling iterations, with replacement. The final column summarizes each cleansing model’s<br />

list interpretation, across the 3 classification alg<strong>or</strong>ithms. The final row <strong>of</strong> graphs summarizes the individual<br />

alg<strong>or</strong>ithms, per cleansing methodology, across all four 4 candidate lists and follows the same col<strong>or</strong> scheme.<br />

Figure 3.5 is the reverse experiment, where the gene list derived from the Bhattacharjee<br />

experiment was used f<strong>or</strong> training the classification model, which was then tested on the Stearman<br />

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