Sample A: Cover Page of Thesis, Project, or Dissertation Proposal
Sample A: Cover Page of Thesis, Project, or Dissertation Proposal
Sample A: Cover Page of Thesis, Project, or Dissertation Proposal
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Conclusion<br />
We have presented a comprehensive protocol f<strong>or</strong> preparing data f<strong>or</strong> gene expression Microarray<br />
analysis, using a suite <strong>of</strong> probe and measurement based filters, and have shown that by so doing<br />
m<strong>or</strong>e reliable probe-target measurements result, whose trends are consistent across independent<br />
experiments. While individual components <strong>of</strong> our protocol have been published elsewhere, to our<br />
knowledge the methods have not been integrated together and the overall effect assessed.<br />
Understanding contributions to a response allows researchers to have m<strong>or</strong>e confidence when<br />
making cross experiment data comparisons, which will facilitate our understanding <strong>of</strong> gene<br />
behavi<strong>or</strong> within a cell. We do expect that this type <strong>of</strong> analysis will only be improved with the<br />
addition <strong>of</strong> m<strong>or</strong>e sophisticated noise reduction methods applied to data prepared in this manner.<br />
Finally, probe based analysis is greatly simplified if carried out with a database system such as<br />
ProbeFATE, which uses the probe as the atomic unit and has been optimized f<strong>or</strong> manipulations<br />
and aggregations that build specific subsets based on user-coupled criteria.<br />
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