Sample A: Cover Page of Thesis, Project, or Dissertation Proposal

the pairwise 2-class classification models, and the accumulated AUC represents the multiclass
performance [3, 10, 13, 14]. The weighting scheme was as follows:
AUC = % auc * (1- (Ci/T))/n-1, (4)
where C is the class numbers, T is the sample numbers, and n is the number of classes. The
weighting scheme was chosen over the average AUC, to compensate for the large class bias.
Classifying the adenocarcinoma samples with little classification ability for the smaller classes
yielded an inflated model AUC.
Results
Eighteen genes are implicated for differentiating NSCLC when the gain criterion threshold is set
at 0.8. These ProbeSets are provided in Table 4.1, along with their HUGO identification,
chromosome location, the calculated gain ration and the GO processes. Investigation of the
gene’s GO processes includes cell proliferation, mitotic cell cycle control, cell motility and
adhesion, inflammatory response, signal transduction, and cell programmed death.
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