Book 1.indb - Journal
Book 1.indb - Journal Book 1.indb - Journal
Swamy NGN et al.: Study of the binding properties of hydroxypropyl guar and its utilization in the formulation and evaluation of metoprolol tartarate tablets Figure 1: Untapped and tapped BD recording for 20/40#MT granules made with 1% w/v of HPG. Figure 2: Untapped and tapped BD recording for 20/40#MT granules made with 1% w/v of NaCMC. RGUHS J Pharm Sci | Vol 2 | Issue 1 | Jan–Mar, 2012 47
Swamy NGN et al.: Study of the binding properties of hydroxypropyl guar and its utilization in the formulation and evaluation of metoprolol tartarate tablets Figure 3: Influence of percentage lactose fines on the angle of repose for 20/40# lactose granules. Figure 4: Influence of percentage lactose fines on the rate of flow for 20/40# lactose granules. talc % w/w on the θ and the fl ow rates is depicted in fi gure 5 and 6. From the studies carried out at “b” and “c” above, it could be concluded that the optimum fi nes concentration was 10% w/w and optimum glidant concentration was 2% w/w of talc powder. (d) Determination of Carr’s index for 20/40 mesh MT granules containing 10% w/w fi nes and blended with 2% w/w of Talc powder The graphical representation for granules made with 1% w/v HPG as binder are shown in fi gure 7 and for granules made with 1% w/v NaCMC is shown in fi gure 8. Carr’s Index is calculated by using the formula CI = (Dt – Db/ Dt) × 100 (4) (e) Hausner’s ratio It is an index of ease for powder fl ow. It is calculated by the following formula, Hausner s ratio Dt ' = (5) Db 48 RGUHS J Pharm Sci | Vol 2 | Issue 1 | Jan–Mar, 2012
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Swamy NGN et al.: Study of the binding properties of hydroxypropyl guar and its utilization in the formulation and evaluation of metoprolol tartarate tablets<br />
Figure 3: Influence of percentage lactose fines on the angle of repose for 20/40# lactose granules.<br />
Figure 4: Influence of percentage lactose fines on the rate of flow for 20/40# lactose granules.<br />
talc % w/w on the θ and the fl ow rates is depicted in<br />
fi gure 5 and 6.<br />
From the studies carried out at “b” and “c” above, it<br />
could be concluded that the optimum fi nes concentration<br />
was 10% w/w and optimum glidant concentration was<br />
2% w/w of talc powder.<br />
(d) Determination of Carr’s index for 20/40 mesh<br />
MT granules containing 10% w/w fi nes and<br />
blended with 2% w/w of Talc powder<br />
The graphical representation for granules made with<br />
1% w/v HPG as binder are shown in fi gure 7 and<br />
for granules made with 1% w/v NaCMC is shown<br />
in fi gure 8. Carr’s Index is calculated by using the<br />
formula<br />
CI = (Dt – Db/ Dt) × 100 (4)<br />
(e) Hausner’s ratio<br />
It is an index of ease for powder fl ow. It is calculated by<br />
the following formula,<br />
Hausner s ratio Dt<br />
' = (5)<br />
Db<br />
48 RGUHS J Pharm Sci | Vol 2 | Issue 1 | Jan–Mar, 2012
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