Tuning Reactivity of Platinum(II) Complexes

complexes, have a lower charge and will associate differently with the DNA. In addition,
Density Functional Theory (DFT) calculations were performed on the geometry–
optimised structures of the studied complexes.
N H 3
H 2 O
P t
N H 3
H 2 N ( C H 2 ) n N H 2
4
H 2 O
P t
N H 3
N H 3
E n P t P r o p P t B u t P t H e x P t O c t P t D e c P t
n = 2 3 4 6 8 1 0
Scheme 7.1: Structures and abbreviations of the investigated dinuclear Pt(II) complexes
7.2 Experimental Section
Chemicals: Cisplatin (cis-PtCl2(NH3)2, 99%) was purchased from Strem Chemicals. The
nucleophiles, viz. thiourea (TU, 99%), N,N-dimethyl-2-thiourea (DMTU, 99%), N,N,N,N-
tetramethyl-2-thiourea (TMTU, 98%) and the ligands: 1,2-diaminoethane (99%), 1,3-
diaminopropane (99%), 1,4-diaminobutane (99%), 1,6-diaminohexane (98%), 1,8-
diaminooctane (98%) and 1,10-diaminodecane (97%), including † NaClO4.H2O (98%)
and HClO4 (70%) were obtained from Aldrich and used without further purification.
AgClO4 (99.99%, Aldrich) was stored under nitrogen and used as supplied. Methanol
(Saarchem) was distilled and dried over magnesium before use. 36 Ultrapure water
(Modulab Systems) was used in all experiments. All other reagents used were of
analytical grade quality.
Caution: † Metal perchlorate complexes and perchloric acid are potentially explosive. They should be
handled with care, and the complexes should be prepared in small quantities.
4 +