Tuning Reactivity of Platinum(II) Complexes

Figure 1.4: DNA-adduct formation with cisplatin leaving two amino groups coordinated on the
platinum atom. The main adducts formed in the interaction cisplatin with DNA: (a) interstrand crosslink;
(b) 1,2-intrastrand cross-link; (c) 1,3-intrastrand cross-link and; (d) protein-DNA cross-link. ..... 7
Figure 1.5: Schematic pathway of a platinum drug in cells showing how sulphur containing
compounds are thought to act as potential drug reserving agents in platinum chemotherapy. ............... 9
Figure 1.6: DNA adducts formed by oxaliplatin 13 . ............................................................................... 11
Figure 1.7: Structure of a sterically hindered platinum(II) complex (ZD0473) that circumvents
cisplatin resistance. ............................................................................................................................. 12
Figure 1.8: Selected Pt(II) metallo-intercalators: terpy = terpyridine, phen = phenanthroline, 4picoline
= 4-methylpyridine, en = 1,2-diaminoethane, and HET = 2-hydroxyethanethiolato
ligand. ................................................................................................................................................... 13
Figure 1.9: Selected Multinuclear platinum(II) complexes with flexible amino- and rigid azine
and azoles ligands. , .............................................................................................................................. 15
Figure 1.10: Structure of extended terpy Pt(II) complexes; blue ring for isoquinoline ring and
red for phenanthroline ring system. .................................................................................................. 18
ii