Tuning Reactivity of Platinum(II) Complexes

4.3.4 Kinetics with NMR
The substitution reaction of pzn as a chloride, i.e. [cis-{PtCl(NH3)2}2-μ-pzn}] +2 with
excess TU (6 equiv.), was studied by 1H and 195Pt NMR spectroscopy. The 1H and 195Pt
NMR spectra of the substitution reaction of the [{cis–PtCl(NH3)2}2–μ–pzn](ClO4)2 with
TU are presented in Figures 4.8 and 4.9, respectively. The NMR spectral arrays were also
used to determine the rate of dechelation of the pyrazine ligand as shown in figure 4.10.
Figure 4.8: 1 H NMR spectra in D2O of the aromatic region of 0.022mM [{cis-PtCl (NH3)2}2-
µ-pzn] +2 reaction with TU at 30°C showing the production of the major
degradation product free pyrazine (L) at δ 8.68 ppm and the starting complex
(A) at δ = 9.04 ppm. These spectra are indicative of the formation of other
minor transient intermediate products.
22