Tuning Reactivity of Platinum(II) Complexes

List of Figures
Figure 1.1 Classification of chemotherapy drugs ……………………………..………...2
Figure 1.2 Chemical structures of selected platinum compounds ……………….4
Figure 1.3 Intracellular hydrolysis and bio-activation of cisplatin in aqueous
solution leading to binding at DNA in the cell nucleus.
……………………………………………………………..……………..……………..……6
Figure 1.4 DNA-adduct formation with cisplatin leaving two amino groups
coordinated on the platinum atom. The main adducts formed in
the interaction cisplatin with DNA: (a) interstrand cross-link; (b)
1,2-intrastrand cross-link; (c) 1,3-intrastrand cross-link and; (d)
protein-DNA cross-link. ………………………………………………….………...7
Figure 1.5 Schematic pathway of a platinum drug in cells showing how
sulphur containing compounds are thought to act as potential
drug reserving agents in platinum chemotherapy ….………………….9
Figure 1.6 DNA adducts formed by oxaliplatin. ………………………………………..11
Figure 1.7 Structure of a sterically hindered platinum(II) complex (ZD0473)
that circumvents cisplatin resistance. ……………………………………..12
Figure 1.8 Selected Pt(II) metallo-intercalators: terpy = terpyridine, phen =
phenanthroline, 4-picoline = 4-methylpyridine, en = 1,2-
diaminoethane, and HET = 2-hydroxyethanethiolato ligand
.……………………………………… ……………..……………..……………..………..13
Figure 1.9 Selected Multinuclear platinum(II) complexes with flexible amino-
and rigid azine and azoles ligands., …………………………………………15
Figure 1.10 Structure of extended terpy Pt(II) complexes………..…………………18
Figure 2.1 Structures of some monofunctional platinum(II) complexes active
against (HCT-116) cell line …………………………………………………….....2
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