hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
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HEXACHLOROBUTADIENE 41<br />
2. HEALTH EFFECTS<br />
Additional processing of the <strong>hexachlorobutadiene</strong> metabolites produces the <strong>com</strong>pounds identified in<br />
the urine (1,1,2,3-tetrachlorobutenoic acid, 1,1,2,3,4-pentachloro-1:3-butadienyl sulfenic acid,<br />
N-acetyl-S-l, 1,2,3,4-pentachlorobutadienyl-L-cysteine, S-l, 1,2,3,4-pentachlorobutadienylmercaptoacetic<br />
acid, 1,1,2,3,4-pentachlorobutadiene methylthioether, and 1,1,2,3,4-pentachlorobutadiene carboxymethylthioether)<br />
(Dekant et al. 1988b; Nash et al. 1984; Reichert and Schutz 1986; Reichert et al. 1985).<br />
A very small portion of the absorbed <strong>hexachlorobutadiene</strong> is oxidized to carbon dioxide. This<br />
pathway can be saturated since an increase in the <strong>hexachlorobutadiene</strong> dose does not cause a<br />
corresponding increase in excretion of labeled carbon dioxide (Dekant et al. 1988b; Payan et al.<br />
1991; Reichert et al. 1985).<br />
2.3.3.3 Dermal Exposure<br />
No studies were located regarding metabolism in humans or animals after dermal exposure to<br />
<strong>hexachlorobutadiene</strong>.<br />
2.3.4 Excretion<br />
2.3.4.1 Inhalation Exposure<br />
No studies were located regarding excretion in humans or animals after inhalation exposure to<br />
<strong>hexachlorobutadiene</strong>.<br />
2.3.4.2 Oral Exposure<br />
No studies were located regarding excretion in humans after oral exposure to <strong>hexachlorobutadiene</strong>.<br />
In animals, <strong>hexachlorobutadiene</strong> and its metabolites are excreted in exhaled air, urine, and feces. In<br />
studies where radiolabeled ( 14 C) <strong>hexachlorobutadiene</strong> was administered at doses of 1, 30, 50, or<br />
100 mg/kg, 4-8% of the dose was removed from the body in the exhaled air as unmetabolized<br />
<strong>hexachlorobutadiene</strong> and carbon dioxide within the 72 hours after <strong>com</strong>pound administration (Dekant<br />
et al. 1988b; Payan et al. 1991; Reichert et al. 1985).