hexachlorobutadiene - Davidborowski.com

HEXACHLOROBUTADIENE 35
2.2.3.8 Cancer
2. HEALTH EFFECTS
No studies were located regarding carcinogenic effects in humans after dermal exposure to
hexachlorobutadiene.
Hexachlorobutadiene did not produce skin papillomas, carcinomas, or tumors at distant sites in mice
after application of dose levels of 2-6 mg/mouse for 440-594 days (Van Duuren et al. 1979). Data
from this exploratory study are not sufficient to rule out carcinogenic effects via dermal exposure.
2 . 3 TOXICOKINETICS
In analogy with other unsaturated chlorinated compounds, hexachlorobutadiene absorption presumably
occurs across the lipid portion of the intestinal matrix rather than by active or protein-facilitated
transport. After absorption, most of the hexachlorobutadiene is carried to the liver where it is
conjugated with glutathione and excreted in the bile. Mono- and bis-substituted glutathione conjugates
are formed. The bile also contains the cysteinyl/glycinyl and cysteinyl derivatives of the glutathione
conjugate. Biliary metabolites are resorbed from the intestines and undergo enterohepatic
recirculation.
Hexachlorobutadiene and its metabolites preferentially distribute to the kidney, liver, adipose deposits,
and possibly the brain. Some hexachlorobutadiene metabolites inhibit mitochondrial metabolism and
react with DNA, resulting in cell death or tumorigenesis. Hexachlorobutadiene metabolites are
excreted in the urine and feces. There is limited degradation to carbon dioxide which is exhaled from
the lungs.
2.3.1 Absorption
2.3.1.1 Inhalation Exposure
No studies were located regarding absorption in humans or animals after inhalation exposure to
hexachlorobutadiene. The occurrence of effects after exposure (de Ceaurriz et al. 1988; Gage 1970)
indicate that absorption does occur.