hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
HEXACHLOROBUTADIENE 35<br />
2.2.3.8 Cancer<br />
2. HEALTH EFFECTS<br />
No studies were located regarding carcinogenic effects in humans after dermal exposure to<br />
<strong>hexachlorobutadiene</strong>.<br />
Hexachlorobutadiene did not produce skin papillomas, carcinomas, or tumors at distant sites in mice<br />
after application of dose levels of 2-6 mg/mouse for 440-594 days (Van Duuren et al. 1979). Data<br />
from this exploratory study are not sufficient to rule out carcinogenic effects via dermal exposure.<br />
2 . 3 TOXICOKINETICS<br />
In analogy with other unsaturated chlorinated <strong>com</strong>pounds, <strong>hexachlorobutadiene</strong> absorption presumably<br />
occurs across the lipid portion of the intestinal matrix rather than by active or protein-facilitated<br />
transport. After absorption, most of the <strong>hexachlorobutadiene</strong> is carried to the liver where it is<br />
conjugated with glutathione and excreted in the bile. Mono- and bis-substituted glutathione conjugates<br />
are formed. The bile also contains the cysteinyl/glycinyl and cysteinyl derivatives of the glutathione<br />
conjugate. Biliary metabolites are resorbed from the intestines and undergo enterohepatic<br />
recirculation.<br />
Hexachlorobutadiene and its metabolites preferentially distribute to the kidney, liver, adipose deposits,<br />
and possibly the brain. Some <strong>hexachlorobutadiene</strong> metabolites inhibit mitochondrial metabolism and<br />
react with DNA, resulting in cell death or tumorigenesis. Hexachlorobutadiene metabolites are<br />
excreted in the urine and feces. There is limited degradation to carbon dioxide which is exhaled from<br />
the lungs.<br />
2.3.1 Absorption<br />
2.3.1.1 Inhalation Exposure<br />
No studies were located regarding absorption in humans or animals after inhalation exposure to<br />
<strong>hexachlorobutadiene</strong>. The occurrence of effects after exposure (de Ceaurriz et al. 1988; Gage 1970)<br />
indicate that absorption does occur.