hexachlorobutadiene - Davidborowski.com

HEXACHLOROBUTADIENE 34
2. HEALTH EFFECTS
Renal Effects. Acute-duration dermal exposure in rabbits caused tubular necrosis 24 hours after
exposure at dose levels 388 mg/kg or greater (Duprat and Gradiski 1978). The effects were partly
reversible, as evident by epithelial regeneration 2 and 5 weeks after exposure.
Dermal/Ocular Effects. Skin necrosis was evident at the site of application in rabbits after exposure
of the skin to dose levels of 388 mg/kg hexachlorobutadiene for 8 hours (Duprat and Gradiski 1978).
However, most skin lesions had healed within 2 weeks.
2.2.3.3 lmmunological Effects
No studies were located regarding immunological effects in humans or animals after dermal exposure
to hexachlorobutadiene.
2.2.3.4 Neurological Effects
No studies were located regarding neurological effects in humans after dermal exposure to
hexachlorobutadiene.
Rabbits exposed to doses of 388-1550 mg/kg applied to shaved skin exhibited evidence of aneral
nervous system depression (stupor) during exposure and in the l-2 hour period after exposure
(Duprat and Gradiski 1978).
No studies were located regarding the following health effects in humans or animals after dermal
exposure:
2.2.3.5 Developmental Effects
2.2.3.6 Reproductive Effects
2.2.3.7 Genotoxic Effects
Genotoxicity studies are discussed in Section 2.4.