hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
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HEXACHLOROBUTADIENE 34<br />
2. HEALTH EFFECTS<br />
Renal Effects. Acute-duration dermal exposure in rabbits caused tubular necrosis 24 hours after<br />
exposure at dose levels 388 mg/kg or greater (Duprat and Gradiski 1978). The effects were partly<br />
reversible, as evident by epithelial regeneration 2 and 5 weeks after exposure.<br />
Dermal/Ocular Effects. Skin necrosis was evident at the site of application in rabbits after exposure<br />
of the skin to dose levels of 388 mg/kg <strong>hexachlorobutadiene</strong> for 8 hours (Duprat and Gradiski 1978).<br />
However, most skin lesions had healed within 2 weeks.<br />
2.2.3.3 lmmunological Effects<br />
No studies were located regarding immunological effects in humans or animals after dermal exposure<br />
to <strong>hexachlorobutadiene</strong>.<br />
2.2.3.4 Neurological Effects<br />
No studies were located regarding neurological effects in humans after dermal exposure to<br />
<strong>hexachlorobutadiene</strong>.<br />
Rabbits exposed to doses of 388-1550 mg/kg applied to shaved skin exhibited evidence of aneral<br />
nervous system depression (stupor) during exposure and in the l-2 hour period after exposure<br />
(Duprat and Gradiski 1978).<br />
No studies were located regarding the following health effects in humans or animals after dermal<br />
exposure:<br />
2.2.3.5 Developmental Effects<br />
2.2.3.6 Reproductive Effects<br />
2.2.3.7 Genotoxic Effects<br />
Genotoxicity studies are discussed in Section 2.4.