hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
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HEXACHLOROBUTADIENE 32<br />
2. HEALTH EFFECTS<br />
human risk. Based on this value, cancer risk levels of 10 -4 , 10 -5 , and 10 -6 correspond to exposures of<br />
0.001, 0.0001, 0.00001 mg/kg/day.<br />
2.2.3 Dermal Exposure<br />
2.2.3.1 Death<br />
No studies were located regarding death in humans after dermal exposure to <strong>hexachlorobutadiene</strong>.<br />
During the 14 day observation period some rabbits (2-8) died after 8-hour exposure to doses of<br />
775-1,550 mg/kg applied directly to shaved skin (3.2 cm 2 ), but no deaths occurred in the 388 mg/kg<br />
dose group. The author calculated an LD50 of 1,116 mg/kg from these data (Duprat and Gradiski<br />
1978). Central nervous system depression was evident, as manifested by stupor. Some animals were<br />
weak and anorexic, while others showed signs of dyspnea and cyanosis. The lungs, liver, and<br />
kidneys were congested in animals that died. Death was reportedly due to respiratory or cardiac<br />
failure.<br />
A LOAEL value for lethality in rabbits after acute-duration exposure is recorded in Table 2-3.<br />
2.2.3.2 Systemic Effects<br />
No studies were located regarding respiratory, cardiovascular, gastrointestinal, hematological,<br />
musculoskeletal, hepatic, renal, dermal/ocular, or other effects in humans after dermal exposure to<br />
<strong>hexachlorobutadiene</strong>. Liver, kidney, and dermal/ocular effects were reported in animals. These<br />
effects are discussed below. All LOAEL values for systemic effects in rabbits after acute-duration<br />
exposure are recorded in Table 2-3.<br />
Hepatic Effects. Hydropic changes, fatty degeneration, and glycogen reduction were observed in<br />
rabbits after exposure of the skin to 388 mg/kg or greater <strong>hexachlorobutadiene</strong> for 8 hours (Duprat<br />
and Gradiski 1978). These effects were reversible within 3 weeks.