hexachlorobutadiene - Davidborowski.com

HEXACHLOROBUTADIENE 32
2. HEALTH EFFECTS
human risk. Based on this value, cancer risk levels of 10 -4 , 10 -5 , and 10 -6 correspond to exposures of
0.001, 0.0001, 0.00001 mg/kg/day.
2.2.3 Dermal Exposure
2.2.3.1 Death
No studies were located regarding death in humans after dermal exposure to hexachlorobutadiene.
During the 14 day observation period some rabbits (2-8) died after 8-hour exposure to doses of
775-1,550 mg/kg applied directly to shaved skin (3.2 cm 2 ), but no deaths occurred in the 388 mg/kg
dose group. The author calculated an LD50 of 1,116 mg/kg from these data (Duprat and Gradiski
1978). Central nervous system depression was evident, as manifested by stupor. Some animals were
weak and anorexic, while others showed signs of dyspnea and cyanosis. The lungs, liver, and
kidneys were congested in animals that died. Death was reportedly due to respiratory or cardiac
failure.
A LOAEL value for lethality in rabbits after acute-duration exposure is recorded in Table 2-3.
2.2.3.2 Systemic Effects
No studies were located regarding respiratory, cardiovascular, gastrointestinal, hematological,
musculoskeletal, hepatic, renal, dermal/ocular, or other effects in humans after dermal exposure to
hexachlorobutadiene. Liver, kidney, and dermal/ocular effects were reported in animals. These
effects are discussed below. All LOAEL values for systemic effects in rabbits after acute-duration
exposure are recorded in Table 2-3.
Hepatic Effects. Hydropic changes, fatty degeneration, and glycogen reduction were observed in
rabbits after exposure of the skin to 388 mg/kg or greater hexachlorobutadiene for 8 hours (Duprat
and Gradiski 1978). These effects were reversible within 3 weeks.