hexachlorobutadiene - Davidborowski.com

HEXACHLOROBUTADIENE 30
2. HEALTH EFFECTS
The highest NOAEL values and all LOAEL values from each reliable study for neurotoxicity in each
species and duration category are recorded in Table 2-2 and plotted in Figure 2-2.
2.2.2.5 Reproductive Effects
No studies were located regarding reproductive effects in humans after oral exposure to
hexachlorobutadiene.
In animals, fertility was reduced 100% in Wistar-derived rat dams administered 150 mg/kg/day
hexachlorobutadiene during a 10-week study. The mean litter size and the resorption rate did not
differ significantly from controls in dams fed 15 mg/kg/day during an 18-week study (Harleman and
Seinen 1979). The actual total exposure time for this study is not clear; the rats were exposed for at
least 10 weeks at the high dose and 12 weeks (of an 18-week study) at the low dose. No
determination of a reliable LOAEL or NOAEL value was possible for this study. In another study,
fertility, gestation, viability, and lactation indices were comparable in treated and control groups of
Sprague-Dawley rats at dose levels of 20 mg/kg/day for 148 days (Schwetz et al. 1977). No
significant changes were seen in sperm count or incidence of abnormal sperm in mice exposed to
hexachlorobutadiene (19 mg/kg/day) for 13 weeks (NTP 1991; Yang et al. 1989). Lifetime exposures
up to 20 mg/kg/day did not reveal treatment-related lesions in the reproductive organs (Kociba et al.
1977a).
The highest NOAEL values and all LOAEL values from each reliable study for reproductive effects
in each species and duration category are recorded in Table 2-2 and plotted in Figure 2-2.
2.2.2.6 Developmental Effects
No studies were located regarding developmental effects in humans after oral exposure to
hexachlorobutadiene.
In animal studies, rat dams were fed hexachlorobutadiene at dose levels of 15 mg/kg/day during
gestation (as part of an 18-week study). Rat pup weights were reduced at birth and weaning.
However, embryotoxicity and teratogenicity were not observed at this dose (Harleman and Seinen
1979). In another study, body weight was decreased (p < 0.05) on day 21 of lactation in rat pups