hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
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Cancer<br />
TABLE 2-2. Levels of Significant Exposure to Hexachlorobutadiene - Oral (continued)<br />
Exposure/<br />
LOAEL (effect)<br />
Key to duration/ NOAEL Less serious<br />
Serious<br />
Species Route frequency System (mg/kg/day) (mg/kg/day) (mg/ kg/day)<br />
figure a<br />
21 Rat (F) 2 yr 20 (CEL: kidney tumors) Kociba et al.<br />
1977a<br />
a<br />
The number corresponds to entries in Figure 2- 2.<br />
b<br />
Used to derive an intermediate oral minimal risk level (MRL) of 0.0002 mg/kg/day; dose divided by an uncertainty factor of<br />
1,000 (10 for extrapolation from animals to humans, 10 for use of a LOAEL and 10 for human variability).<br />
Cardio = cardiovascular; d = day(s); (F) = feed; Gastro = gastrointestinal; Gd = gestation day; (GO) = gavage - oil;<br />
Hemato = hematological; Ld = lactation day(s); LOAEL = lowest - observed - adverse - effect level;<br />
Musc/skel = musculoskeletal; NOAEL = no - observed - adverse - effect level; Resp = respiratory; wk = week(s); yr = year(s)<br />
Reference<br />
2. HEALTH EFFECTS<br />
HEXACHLOROBUTADIENE 22