hexachlorobutadiene - Davidborowski.com

Cancer
TABLE 2-2. Levels of Significant Exposure to Hexachlorobutadiene - Oral (continued)
Exposure/
LOAEL (effect)
Key to duration/ NOAEL Less serious
Serious
Species Route frequency System (mg/kg/day) (mg/kg/day) (mg/ kg/day)
figure a
21 Rat (F) 2 yr 20 (CEL: kidney tumors) Kociba et al.
1977a
a
The number corresponds to entries in Figure 2- 2.
b
Used to derive an intermediate oral minimal risk level (MRL) of 0.0002 mg/kg/day; dose divided by an uncertainty factor of
1,000 (10 for extrapolation from animals to humans, 10 for use of a LOAEL and 10 for human variability).
Cardio = cardiovascular; d = day(s); (F) = feed; Gastro = gastrointestinal; Gd = gestation day; (GO) = gavage - oil;
Hemato = hematological; Ld = lactation day(s); LOAEL = lowest - observed - adverse - effect level;
Musc/skel = musculoskeletal; NOAEL = no - observed - adverse - effect level; Resp = respiratory; wk = week(s); yr = year(s)
Reference
2. HEALTH EFFECTS
HEXACHLOROBUTADIENE 22