hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
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7 Mouse (F) 13 wk Resp<br />
Cardio<br />
Gastro<br />
Musc/skel<br />
Hepatic<br />
Renal<br />
Neurological<br />
TABLE 2-2. Levels of Significant Exposure to Hexachlorobutadiene - Oral (continued)<br />
8 Rat (GO) 13 wk<br />
9 Rat (F) 148 d<br />
10 Rat (F) 10-18 wk<br />
11 Rat (F) 30 d<br />
12 Mouse (F) 13 wk<br />
Developmental<br />
Exposure/<br />
13 Rat (F) 43 d<br />
Gdl-22;<br />
Ld1-21<br />
14 Rat (F) 6 wk<br />
Derm/oc<br />
Other<br />
19.2<br />
19.2<br />
19.2<br />
19.2<br />
19.2<br />
0.2 b (tubular<br />
degeneration)<br />
19.2<br />
1.5 4.9 (body weight gain<br />
reduced 49% in<br />
males)<br />
15.6<br />
20<br />
15<br />
100<br />
19.2<br />
2 20 (neonatal weight<br />
decreased 13%)<br />
15 (reduced pup<br />
weight, 16-19%)<br />
LOAEL (effect)<br />
Key to duration/ NOAEL Less serious<br />
Serious<br />
Species Route frequency System (mg/kg/day) (mg/kg/day) (mg/ kg/day)<br />
figure a<br />
Reference<br />
NTP 1991, Yang<br />
et al. 1989<br />
Harleman and<br />
Seinen 1979<br />
Schwetz et al.<br />
1977<br />
150 (ataxia, Harleman and<br />
demyelination and Seinen 1979<br />
degeneration of<br />
femoral nerve<br />
fiber)<br />
Kociba et al.<br />
1971<br />
NTP 1991, Yang<br />
et al. 1989<br />
Schwetz et al.<br />
1977<br />
Harleman and<br />
Seinen 1979<br />
2. HEALTH EFFECTS<br />
HEXACHLOROBUTADIENE 20
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