hexachlorobutadiene - Davidborowski.com

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TABLE 2-2. Levels of Significant Exposure to Hexachlorobutadiene - Oral Exposure/ LOAEL (effect) Key to duration/ NOAEL Less serious Serious Species Route frequency System (mg/kg/day) (mg/kg/day) (mg/ kg/day) figure a ACUTE EXPOSURE Systemic 1 Rat (F) 14 d Hepatic 35 Renal INTERMEDIATE EXPOSURE Systemic 2 Rat (GO) 13 wk Other Hepatic Hemato Renal Other 3 Rat (F) 30 d Resp Cardio Gastro Hemato Hepatic Renal Other 2.5 15.6 1 2.5 100 100 100 3 10 10 100 4.6 (proximal convoluted tubule degeneration) 4.4 (body weight reduced 9.5% in females) 6.3 (increased cytoplasmic basophilia) 2.5 (degeneration proximal tubules) 10 (increased hemoglobin concentration) 30 (centri lobular hepatocellular swelling) 30 (tubular degeneration, necrosis) (thyroid, para- thyroid, pituitary and adrenal glands) 6.3 (body weight decreased 29% in females and 13% in males) Reference Harleman and Seinen 1979 Harleman and Seinen 1979 Kociba et al. 1971 2. HEALTH EFFECTS HEXACHLOROBUTADIENE 18
4 Rat (F) 10-18 wk Renal 5 6 TABLE 2-2. Levels of Significant Exposure to Hexachlorobutadiene - Oral (continued) Rat Rat Exposure/ (F) 4 wk Other (F) 148 d Resp Cardio Gast ro Hemato Musc/ske l Hepatic Rena l 15 (maternal body weight decreased 15%) 15 (tubular degeneration, necrosis) Harleman and Seinen 1979 Hepa t i c 1.25 5 (absolute liver 20 (increased plasma Jonker et at. weight decreased aspartate amino- 1993b 41%) transferase and Rena l 1.25 5 (tubular cytomegaly and decreased plasma creatinine) Other 1.25 5 (body weight Other decreased 10% in males and 15% in females, decreased adrenal weight, 17%) 20 20 20 20 20 20 0.2 2 (tubular degeneration) 2 20 (body weight gain LOAEL (effect) Key to duration/ NOAEL Less serious Serious Species Route frequency System (mg/kg/day) (mg/kg/day) (mg/ kg/day) figure a reduced 8-9% in males and 5-17% in females) bi l i rubi n) Reference Schwetz et al. 1977 2. HEALTH EFFECTS HEXACHLOROBUTADIENE 19
Page 1 and 2: TOXICOLOGICAL PROFILE FOR HEXACHLOR
Page 3: HEXACHLOROBUTADIENE iii UPDATE STAT
Page 20 and 21: HEXACHLOROBUTADIENE 2 1.1 WHAT IS H
Page 22 and 23: HEXACHLOROBUTADIENE 4 1. PUBLIC HEA
Page 24 and 25: HEXACHLOROBUTADIENE 6 1. PUBLIC HEA
Page 27 and 28: HEXACHLOROBUTADIENE 9 2.1 INTRODUCT
Page 29 and 30: HEXACHLOROBUTADIENE 11 2. HEALTH EF
Page 31 and 32: FIGURE 2-1 Levels of Significant Ex
Page 35: HEXACHLOROBUTADIENE 17 2. HEALTH EF
Page 39 and 40: Reproductive 15 Rat 16 Rat 17 Mouse
Page 41 and 42: FIGURE 2-2 Levels of Significant Ex
Page 43 and 44: E psure to Hexachlorobutadiene - ra
Page 51 and 52: Species ACUTE EXPOSURE Death System
Page 53 and 54: HEXACHLOROBUTADIENE 35 2.2.3.8 Canc
Page 55 and 56: HEXACHLOROBUTADIENE 37 2.3.2 Distri
Page 81: HEXACHLOROBUTADIENE 63 2.9 ADEQUACY
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HEXACHLOROBUTADIENE 68 2. HEALTH EF
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HEXACHLOROBUTADIENE 70 2.9.3 On-goi
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HEXACHLOROBUTADIENE 75 4.1 PRODUCTI
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HEXACHLOROBUTADIENE 79 5.1 OVERVIEW
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HEXACHLOROBUTADIENE 83 5.2.2 Water
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HEXACHLOROBUTADIENE 85 5. POTENTIAL
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HEXACHLOROBUTADIENE 87 5.4.3 Sedime
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HEXACHLOROBUTADIENE 89 5.7.1 Identi
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HEXACHLOROBUTADIENE 91 5. POTENTIAL
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HEXACHLOROBUTADIENE 94 6. ANALYTICA
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HEXACHLOROBUTADIENE 99 6. ANALYTICA
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HEXACHLOROBUTADIENE 101 7. REGULATI
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HEXACHLOROBUTADIENE 106 8. REFERENC
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HEXACHLOROBUTADIENE 130 9. GLOSSARY
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HEXACHLOROBUTADIENE 132 9. GLOSSARY
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HEXACHLOROBUTADIENE A-l Chapter 1 P
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HEXACHLOROBUTADIENE A-5 APPENDIX A
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