hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
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4 Rat (F) 10-18 wk Renal<br />
5<br />
6<br />
TABLE 2-2. Levels of Significant Exposure to Hexachlorobutadiene - Oral (continued)<br />
Rat<br />
Rat<br />
Exposure/<br />
(F) 4 wk<br />
Other<br />
(F) 148 d Resp<br />
Cardio<br />
Gast ro<br />
Hemato<br />
Musc/ske l<br />
Hepatic<br />
Rena l<br />
15 (maternal body<br />
weight decreased<br />
15%)<br />
15 (tubular<br />
degeneration,<br />
necrosis)<br />
Harleman and<br />
Seinen 1979<br />
Hepa t i c 1.25 5 (absolute liver 20 (increased plasma Jonker et at.<br />
weight decreased aspartate amino- 1993b<br />
41%) transferase and<br />
Rena l 1.25 5 (tubular cytomegaly<br />
and decreased<br />
plasma creatinine)<br />
Other 1.25 5 (body weight<br />
Other<br />
decreased 10% in<br />
males and 15% in<br />
females, decreased<br />
adrenal weight,<br />
17%)<br />
20<br />
20<br />
20<br />
20<br />
20<br />
20<br />
0.2 2 (tubular<br />
degeneration)<br />
2 20 (body weight gain<br />
LOAEL (effect)<br />
Key to duration/ NOAEL Less serious<br />
Serious<br />
Species Route frequency System (mg/kg/day) (mg/kg/day) (mg/ kg/day)<br />
figure a<br />
reduced 8-9% in<br />
males and 5-17% in<br />
females)<br />
bi l i rubi n)<br />
Reference<br />
Schwetz et al.<br />
1977<br />
2. HEALTH EFFECTS<br />
HEXACHLOROBUTADIENE 19