hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
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TABLE 2-2. Levels of Significant Exposure to Hexachlorobutadiene - Oral<br />
Exposure/<br />
LOAEL (effect)<br />
Key to duration/ NOAEL Less serious<br />
Serious<br />
Species Route frequency System (mg/kg/day) (mg/kg/day) (mg/ kg/day)<br />
figure a<br />
ACUTE EXPOSURE<br />
Systemic<br />
1 Rat (F) 14 d Hepatic 35<br />
Renal<br />
INTERMEDIATE EXPOSURE<br />
Systemic<br />
2 Rat (GO) 13 wk<br />
Other<br />
Hepatic<br />
Hemato<br />
Renal<br />
Other<br />
3 Rat (F) 30 d Resp<br />
Cardio<br />
Gastro<br />
Hemato<br />
Hepatic<br />
Renal<br />
Other<br />
2.5<br />
15.6<br />
1<br />
2.5<br />
100<br />
100<br />
100<br />
3<br />
10<br />
10<br />
100<br />
4.6 (proximal<br />
convoluted tubule<br />
degeneration)<br />
4.4 (body weight<br />
reduced 9.5% in<br />
females)<br />
6.3 (increased<br />
cytoplasmic<br />
basophilia)<br />
2.5 (degeneration<br />
proximal tubules)<br />
10 (increased hemoglobin<br />
concentration)<br />
30 (centri lobular<br />
hepatocellular<br />
swelling)<br />
30 (tubular<br />
degeneration,<br />
necrosis)<br />
(thyroid, para-<br />
thyroid, pituitary<br />
and adrenal glands)<br />
6.3 (body weight<br />
decreased 29% in<br />
females and 13%<br />
in males)<br />
Reference<br />
Harleman and<br />
Seinen 1979<br />
Harleman and<br />
Seinen 1979<br />
Kociba et al.<br />
1971<br />
2. HEALTH EFFECTS<br />
HEXACHLOROBUTADIENE 18