hexachlorobutadiene - Davidborowski.com

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TABLE 2-1. Levels of Significant Exposure to Hexachlorobutadiene - Inhalation Exposure/ LOAEL (effect) Less serious Serious Species Route frequency System (mg/kg/day) (mg/kg/day) (mg/kg/day) Reference Key to duration/ NOAEL f igure a ACUTE EXPOSURE Death 1 Mouse Systemic 2 Rat 3 Mouse 4 Mouse INTERMEDIATE EXPOSURE Developmental 5 Rat Reproductive 5 d 7hr/d 5 d Other 10 50 (body weight 7h r/d reduced 14%) 15 min Resp 4 hr Renal Gd 6-20 6hr/d 6 Rat 15 d Gd 6-20 6hr/d a The number corresponds to entries in Figure 2-1. 155 (decreased respiratory rate 36%) 2.75 (damaged cortical proximal tubules) 10 15 (fetal body weight reduced 9.5% in males and 12.5% in f ema l es) 15 50 100% mortality) d = day(s); Gd = gestation day; hr = hour(s); LOAEL = lowest - observed -adverse -effect level; min = minute(s); NOAEL = no-observed - adverse - effect level; Resp = respiratory NIOSH 1981 NIOSH 1981 de Ceaurriz et al. 1988 de Ceaurriz et al. 1988 Saillenfait et al. 1989 Saillenfait et al. 1989 2. HEALTH EFFECTS HEXACHLOROBUTADIENE 12
FIGURE 2-1 Levels of Significant Exposure to Hexachlorobutadiene - Inhalation o.:[ 1m lot 0.01 0.001 0.0001 0.00001 0.000001 0.0000001 ACUTE INTERMEDIATE (514 Days) (1 5-364 Days) 3m Systemic 4m 2r 2r Key m Mouse 0 LOAEL for serious effects (animals) r Rat 0 LOAEL for less serious effects (animals) 0 NOAEL (animals) The number next to each point corresponds to entries in Table 2-1. 5r 5r 6r 10-7 Estimated Human Cancer
Page 1 and 2: TOXICOLOGICAL PROFILE FOR HEXACHLOR
Page 3: HEXACHLOROBUTADIENE iii UPDATE STAT
Page 20 and 21: HEXACHLOROBUTADIENE 2 1.1 WHAT IS H
Page 22 and 23: HEXACHLOROBUTADIENE 4 1. PUBLIC HEA
Page 24 and 25: HEXACHLOROBUTADIENE 6 1. PUBLIC HEA
Page 27 and 28: HEXACHLOROBUTADIENE 9 2.1 INTRODUCT
Page 29: HEXACHLOROBUTADIENE 11 2. HEALTH EF
Page 33 and 34: HEXACHLOROBUTADIENE 15 2. HEALTH EF
Page 37 and 38: 4 Rat (F) 10-18 wk Renal 5 6 TABLE
Page 39 and 40: Reproductive 15 Rat 16 Rat 17 Mouse
Page 41 and 42: FIGURE 2-2 Levels of Significant Ex
Page 43 and 44: E psure to Hexachlorobutadiene - ra
Page 51 and 52: Species ACUTE EXPOSURE Death System
Page 53 and 54: HEXACHLOROBUTADIENE 35 2.2.3.8 Canc
Page 55 and 56: HEXACHLOROBUTADIENE 37 2.3.2 Distri
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HEXACHLOROBUTADIENE 63 2.9 ADEQUACY
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HEXACHLOROBUTADIENE 66 2. HEALTH EF
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HEXACHLOROBUTADIENE 68 2. HEALTH EF
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HEXACHLOROBUTADIENE 70 2.9.3 On-goi
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HEXACHLOROBUTADIENE 75 4.1 PRODUCTI
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HEXACHLOROBUTADIENE 79 5.1 OVERVIEW
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HEXACHLOROBUTADIENE 83 5.2.2 Water
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HEXACHLOROBUTADIENE 85 5. POTENTIAL
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HEXACHLOROBUTADIENE 87 5.4.3 Sedime
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HEXACHLOROBUTADIENE 89 5.7.1 Identi
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HEXACHLOROBUTADIENE 91 5. POTENTIAL
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HEXACHLOROBUTADIENE 94 6. ANALYTICA
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HEXACHLOROBUTADIENE 99 6. ANALYTICA
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HEXACHLOROBUTADIENE 101 7. REGULATI
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HEXACHLOROBUTADIENE 106 8. REFERENC
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HEXACHLOROBUTADIENE 130 9. GLOSSARY
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HEXACHLOROBUTADIENE 132 9. GLOSSARY
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HEXACHLOROBUTADIENE A-l Chapter 1 P
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HEXACHLOROBUTADIENE A-5 APPENDIX A
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