hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
hexachlorobutadiene - Davidborowski.com
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TABLE 2-1. Levels of Significant Exposure to Hexachlorobutadiene - Inhalation<br />
Exposure/ LOAEL (effect)<br />
Less serious Serious<br />
Species Route frequency System (mg/kg/day) (mg/kg/day) (mg/kg/day) Reference<br />
Key to duration/ NOAEL<br />
f igure a<br />
ACUTE EXPOSURE<br />
Death<br />
1 Mouse<br />
Systemic<br />
2 Rat<br />
3 Mouse<br />
4 Mouse<br />
INTERMEDIATE EXPOSURE<br />
Developmental<br />
5 Rat<br />
Reproductive<br />
5 d<br />
7hr/d<br />
5 d Other 10 50 (body weight<br />
7h r/d reduced 14%)<br />
15 min Resp<br />
4 hr Renal<br />
Gd 6-20<br />
6hr/d<br />
6 Rat 15 d<br />
Gd 6-20<br />
6hr/d<br />
a The number corresponds to entries in Figure 2-1.<br />
155 (decreased<br />
respiratory rate<br />
36%)<br />
2.75 (damaged cortical<br />
proximal tubules)<br />
10 15 (fetal body weight<br />
reduced 9.5% in<br />
males and 12.5% in<br />
f ema l es)<br />
15<br />
50 100% mortality)<br />
d = day(s); Gd = gestation day; hr = hour(s); LOAEL = lowest - observed -adverse -effect level; min = minute(s);<br />
NOAEL = no-observed - adverse - effect level; Resp = respiratory<br />
NIOSH 1981<br />
NIOSH 1981<br />
de Ceaurriz<br />
et al. 1988<br />
de Ceaurriz<br />
et al. 1988<br />
Saillenfait<br />
et al. 1989<br />
Saillenfait<br />
et al. 1989<br />
2. HEALTH EFFECTS<br />
HEXACHLOROBUTADIENE 12
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