hexachlorobutadiene - Davidborowski.com

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HEXACHLOROBUTADIENE 128 8. REFERENCES *Verschueren K. 1983. Handbook of environmental data on organic chemicals. Van Nostrand Reinhold Company, New York, NY: pp. 717-718. *Walters SM. 1990. Clean-up techniques for pesticides in fatty foods. Anal Chim Acta 236:77-82. *Wang F, Ji Z, Wang D. 1991. A rapid pretreatment procedure for determining trace organochlorine compounds in biological samples by capillary gas chromatography. Microchemical Journal 44 : 67-7 1. *Wild D, Schutz S, Reichert D. 1986. Mutagenicity of the mercapturic acid and other S-containing derivatives of hexachloro-1,3-butadiene. Carcinogenesis 7:431-434. *Wolf CR, Berry PN, Nash JA, et al. 1984. Role of microsomal and cytosolic glutathione Stransferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity. J Pharmacol Exp Ther 228 : 202-208. *Yang RS. 1988. Hexachloro-1,3-butadiene: toxicology, metabolism, and mechanisms of toxicity. Rev Environ Contam Toxicol 101: 121-137. *Yang RS, Abdo KM, Elwell MR. 1989. Subchronic toxicology studies of hexachloro-1,3-butadiene (HCBD) in B6C3F1 mice by dietary incorporation. JEPTO 9:323-332. *Yip G. 1976. Survey of hexachloro-1,3-butadiene in fish, eggs, milk, and vegetables. J Assoc Off Anal Chem 59:559-561. *Yurawecz MP, Dreifuss PA, Kamps LR. 1976. Determination of hexachloro-1,3-butadiene in spinach, eggs, fish, and milk by electron capture gas-liquid chromatography. J Assoc Off Anal Chem 59:552-558. *Zoeteman BC, Harmsen K, Linders JB, et al. 1980. Persistent organic pollutants in river water and groundwater in the Netherlands. Chemosphere 9:231-249.

HEXACHLOROBUTADIENE 129 9. GLOSSARY Acute Exposure - Exposure to a chemical for a duration of 14 days or less, as specified in the Toxicological Profiles. Adsorption Coefficient (Koc) - The ratio of the amount of a chemical adsorbed per unit weight of organic carbon in the soil or sediment to the concentration of the chemical in solution at equilibrium. Adsorption Ratio (Kd) - The amount of a chemical adsorbed by a sediment or soil (i.e., the solid phase) divided by the amount of chemical in the solution phase, which is in equilibrium with the solid phase, at a fixed solid/solution ratio. It is generally expressed in micrograms of chemical sorbed per gram of soil or sediment. Bioconcentration Factor (BCF) - The quotient of the concentration of a chemical in aquatic organisms at a specific time or during a discrete time period of exposure divided by the concentration in the surrounding water at the same time or during the same period. Cancer Effect Level (CEL) - The lowest dose of chemical in a study, or group of studies, that produces significant increases in the incidence of cancer (or tumors) between the exposed population and its appropriate control. Carcinogen - A chemical capable of inducing cancer. Ceiling Value - A concentration of a substance that should not be exceeded, even instantaneously. Chronic Exposure - Exposure to a chemical for 365 days or more, as specified in the Toxicological Profiles. Developmental Toxicity - The occurrence of adverse effects on the developing organism that may result from exposure to a chemical prior to conception (either parent), during prenatal development, or postnatally to the time of sexual maturation, Adverse developmental effects may be detected at any point in the life span of the organism.

HEXACHLOROBUTADIENE 128<br />

8. REFERENCES<br />

*Verschueren K. 1983. Handbook of environmental data on organic chemicals. Van Nostrand<br />

Reinhold Company, New York, NY: pp. 717-718.<br />

*Walters SM. 1990. Clean-up techniques for pesticides in fatty foods. Anal Chim Acta 236:77-82.<br />

*Wang F, Ji Z, Wang D. 1991. A rapid pretreatment procedure for determining trace<br />

organochlorine <strong>com</strong>pounds in biological samples by capillary gas chromatography. Microchemical<br />

Journal 44 : 67-7 1.<br />

*Wild D, Schutz S, Reichert D. 1986. Mutagenicity of the mercapturic acid and other S-containing<br />

derivatives of hexachloro-1,3-butadiene. Carcinogenesis 7:431-434.<br />

*Wolf CR, Berry PN, Nash JA, et al. 1984. Role of microsomal and cytosolic glutathione Stransferases<br />

in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity. J<br />

Pharmacol Exp Ther 228 : 202-208.<br />

*Yang RS. 1988. Hexachloro-1,3-butadiene: toxicology, metabolism, and mechanisms of toxicity.<br />

Rev Environ Contam Toxicol 101: 121-137.<br />

*Yang RS, Abdo KM, Elwell MR. 1989. Subchronic toxicology studies of hexachloro-1,3-butadiene<br />

(HCBD) in B6C3F1 mice by dietary incorporation. JEPTO 9:323-332.<br />

*Yip G. 1976. Survey of hexachloro-1,3-butadiene in fish, eggs, milk, and vegetables. J Assoc Off<br />

Anal Chem 59:559-561.<br />

*Yurawecz MP, Dreifuss PA, Kamps LR. 1976. Determination of hexachloro-1,3-butadiene in<br />

spinach, eggs, fish, and milk by electron capture gas-liquid chromatography. J Assoc Off Anal Chem<br />

59:552-558.<br />

*Zoeteman BC, Harmsen K, Linders JB, et al. 1980. Persistent organic pollutants in river water and<br />

groundwater in the Netherlands. Chemosphere 9:231-249.

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