hexachlorobutadiene - Davidborowski.com

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HEXACHLOROBUTADIENE 100 6.3.2 On-going Studies 6. ANALYTICAL METHODS No information was located concerning on-going studies for improving methods of analysis of hexachlorobutadiene, its metabolites, or other biomarkers of exposure and effect to hexachlorobutadiene in biological materials or environmental samples.
HEXACHLOROBUTADIENE 101 7. REGULATIONS AND ADVISORIES Because of its potential to cause adverse health effects in exposed people, a number of regulations and guidelines have been established for hexachlorobutadiene by various international, federal, and state agencies. These values are summarized in Table 7-l. The ATSDR has calculated an intermediate-duration exposure oral MRL of 0.0002 mg/kg/day, based on a LOAEL of 0.2 mg/kg/day for the presence of kidney damage in female mice (NTP 1991). The EPA has derived a chronic oral RfD of 2x10 -4 mg/kg/day for hexachlorobutadiene (EPA 1993). This RfD is based on a LOAEL of 0.5 mg/kg/day for renal effects in mice exposed via the diet for 13 weeks (Yang et al. 1989). Since this RfD is currently under review by EPA and has been withdrawn from EPA’s Integrated’Risk Information System (IRIS 1993), it is subject to change.
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TOXICOLOGICAL PROFILE FOR HEXACHLOR
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HEXACHLOROBUTADIENE iii UPDATE STAT
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HEXACHLOROBUTADIENE 2 1.1 WHAT IS H
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HEXACHLOROBUTADIENE 4 1. PUBLIC HEA
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HEXACHLOROBUTADIENE 6 1. PUBLIC HEA
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HEXACHLOROBUTADIENE 9 2.1 INTRODUCT
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HEXACHLOROBUTADIENE 11 2. HEALTH EF
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FIGURE 2-1 Levels of Significant Ex
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4 Rat (F) 10-18 wk Renal 5 6 TABLE
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Reproductive 15 Rat 16 Rat 17 Mouse
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FIGURE 2-2 Levels of Significant Ex
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E psure to Hexachlorobutadiene - ra
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Species ACUTE EXPOSURE Death System
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HEXACHLOROBUTADIENE 35 2.2.3.8 Canc
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HEXACHLOROBUTADIENE 37 2.3.2 Distri
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hexachlorobutadiene - Davidborowski.com

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