hexachlorobutadiene - Davidborowski.com

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HEXACHLOROBUTADIENE 90 5. POTENTIAL FOR HUMAN EXPOSURE which identify the relationship between absorption and the matrix of soils, sediments, and foods would be useful in establishing whether or not absorption is significantly affected by such factors. Food Chain Bioaccumulation. Bioconcentration factors have been determined for algae, shellfish, and fish and exhibit a wide range (29-17,000) (EPA 1976; Oliver and Niimi 1983; Pearson and McConnell 1975). This wide range may be explained in part by species differences in metabolism or differences in concentrations tested. Studies also indicate that hexachlorobutadiene preferentially accumulates in the livers of fish. Further studies which might explain the wide range of BCF values would be helpful. No information was located regarding the bioaccumulation of hexachlorobutadiene in plants or aquatic organisms. More information is needed to determine the importance of terrestrial/aquatic food chain bioaccumulation as a potential human exposure pathway. Exposure Levels in Environmental Media. Data are available on the occurrence of hexachlorobutadiene in air, water, and foodstuff. The majority of the monitoring data on hexachlorobutadiene are outdated and therefore more recent information on the levels typically found in the environment would allow for more accurate estimation of human exposures, and could also serve to indicate time-dependent trends when compared with older data. No data were located regarding the occurrence of hexachlorobutadiene in groundwater or soil. Reliable monitoring data for the levels of hexachlorobutadiene in contaminated media at hazardous waste sites are needed so that the information obtained on levels of hexachlorobutadiene in the environment can be used in combination with the known body burden of hexachlorobutadiene to assess the potential risk of adverse health effects in populations living in the vicinity of hazardous waste sites. Exposure Levels in Humans. Hexachlorobutadiene has been detected in human adipose tissues and blood (Bristol et al. 1982; Mes et al. 1985). Studies which establish a correlation between exposure levels in environmental media and the resulting levels in human tissues and excreta would be valuable in predicting exposures and corresponding health risks in humans who live at or near hazardous waste sites and who are likely to be exposed to hexachlorobutadiene. This information is necessary for assessing the need to conduct health studies on these populations.
HEXACHLOROBUTADIENE 91 5. POTENTIAL FOR HUMAN EXPOSURE Exposure Registries. No exposure registries for hexachlorobutadiene were located. This substance is not currently one of the compounds for which a subregistry has been established in the National Exposure Registry. The substance will be considered in the future when chemical selection is made for subregistries to be established. The information that is amassed in the National Exposure Registry facilitates the epidemiological research needed to assess adverse health outcomes that may be related to exposure to this substance. 5.7.2 On-going Studies No on-going studies were located regarding the environmental fate or potential for human exposure to hexachlorobutadiene.
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TOXICOLOGICAL PROFILE FOR HEXACHLOR
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HEXACHLOROBUTADIENE iii UPDATE STAT
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HEXACHLOROBUTADIENE 2 1.1 WHAT IS H
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HEXACHLOROBUTADIENE 4 1. PUBLIC HEA
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HEXACHLOROBUTADIENE 6 1. PUBLIC HEA
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HEXACHLOROBUTADIENE 9 2.1 INTRODUCT
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HEXACHLOROBUTADIENE 11 2. HEALTH EF
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FIGURE 2-1 Levels of Significant Ex
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4 Rat (F) 10-18 wk Renal 5 6 TABLE
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Reproductive 15 Rat 16 Rat 17 Mouse
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FIGURE 2-2 Levels of Significant Ex
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E psure to Hexachlorobutadiene - ra
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Species ACUTE EXPOSURE Death System
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HEXACHLOROBUTADIENE 35 2.2.3.8 Canc
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HEXACHLOROBUTADIENE 37 2.3.2 Distri
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Page 81: HEXACHLOROBUTADIENE 63 2.9 ADEQUACY
Page 88 and 89: HEXACHLOROBUTADIENE 70 2.9.3 On-goi
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Page 97 and 98: HEXACHLOROBUTADIENE 79 5.1 OVERVIEW
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Page 112: HEXACHLOROBUTADIENE 94 6. ANALYTICA
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Page 124 and 125: HEXACHLOROBUTADIENE 106 8. REFERENC
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Page 156 and 157: HEXACHLOROBUTADIENE A-5 APPENDIX A
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