Identification of important interactions between subchondral bone ...
Identification of important interactions between subchondral bone ...
Identification of important interactions between subchondral bone ...
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CHAPTER 5<br />
CHAPTER 5: PAPER II<br />
PAPER II<br />
___________________________________________________________________________<br />
Introductory remarks<br />
This manuscript shows the effect <strong>of</strong> glucocorticoids on <strong>bone</strong> and/or cartilage, performed in pre-<br />
clinical models. The novel ex vivo femoral head model (PAPER I) was used to investigate the<br />
effect <strong>of</strong> glucocorticoids on a <strong>bone</strong>/cartilage unit, whereas the articular cartilage ex vivo model and<br />
the osteoclast and osteoblast cell cultures were used to investigate the effects on either <strong>bone</strong> or<br />
cartilage. This manuscript highlights the importance <strong>of</strong> the individual cell type and verifies the<br />
novel ex vivo femoral head model as a useful screening model for potential drugs.<br />
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