Identification of important interactions between subchondral bone ...
Identification of important interactions between subchondral bone ...
Identification of important interactions between subchondral bone ...
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272 Cartilage 2(3)<br />
Figure 5. Cytokines increase the osteoclast number and resorption <strong>of</strong> <strong>bone</strong>. The conditioned media from the 4 experiments with 4<br />
individual age groups were assessed by the osteoclast number measured by TRAP activity (A) and the collagen type I resorption marker,<br />
CTX-I (B). Each graph represents the accumulated measurements from days 4, 7, and 10 except from 12-week-old mice (only day 10).<br />
Catabolic stimulation increases the osteoclast number in all 4 experiments, whereas the anabolic stimulation decreases the osteoclast<br />
number in the experiments with 6- and 9-week-old mice (A). Cytokines (O + T) also increase the total collagen type I resorption in the<br />
experiments with 6-, 9-, and 12-week-old mice (B). *P < 0.05. **P < 0.01. ***P < 0.001.<br />
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