Identification of important interactions between subchondral bone ...
Identification of important interactions between subchondral bone ...
Identification of important interactions between subchondral bone ...
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Preface<br />
Preface<br />
The work presented in this thesis was performed in collaboration <strong>between</strong> Nordic Bioscience<br />
A/S and the University <strong>of</strong> Copenhagen under the industrial PhD agreement and with the<br />
supervision <strong>of</strong> Pr<strong>of</strong>. Morten Asser Karsdal (company supervisor), Dr. Anne-Christine Bay Jensen<br />
(project supervisor, company), Dr. Kim Henriksen (project supervisor, company), and Associate<br />
Pr<strong>of</strong>. Søren Tvorup Christensen (university supervisor). The work was carried out in the period<br />
ranging from October 2008 to November 2011.<br />
The PhD work includes four original research papers listed below. Three papers<br />
have been accepted and published, and one is under review. The individual articles are referred to<br />
in the present thesis by their roman numerals.<br />
The PhD thesis consists <strong>of</strong> an introduction to the topics <strong>of</strong> the four papers, the<br />
four papers, and a general conclusion.<br />
Paper I:<br />
Characterization <strong>of</strong> an Ex vivo Femur Head Model Assessed by Markers <strong>of</strong> Bone and<br />
Cartilage Turnover<br />
Suzi Hoegh Madsen, Anne S<strong>of</strong>ie Goettrup, Gedske Thomsen, Søren Tvorup Christensen,<br />
Nikolaj Schultz, Kim Henriksen, Anne-Christine Bay-Jensen, and Morten Asser Karsdal<br />
Cartilage 2011;2(3):265–278<br />
Paper II:<br />
Glucocorticoids exert context-dependent effects on cells <strong>of</strong> the joint in vitro<br />
Suzi H. Madsen, Kim V. Andreassen, Søren T. Christensen, Morten A. Karsdal,<br />
Francis M. Sverdrup, Anne-Christine Bay-Jensen, and Kim Henriksen<br />
Steroids 2011;76(13):1474-1482<br />
Paper III:<br />
Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated<br />
with different molecular characteristics <strong>of</strong> aggrecan and separated in time ex vivo<br />
Suzi Hoegh Madsen, Eren Ufuk Sumer, Anne-Christine Bay-Jensen, Bodil-Cecilie Sondergaard,<br />
Per Qvist, and Morten Asser Karsdal<br />
Biomarkers 2010;15(3):266-276<br />
Paper IV:<br />
Metalloproteinase and cysteine protease pr<strong>of</strong>iling in normal and Osteoarthritic cartilage<br />
Suzi Hoegh Madsen, Kim Henriksen, Søren Tvorup Christensen, Morten Asser Karsdal, and<br />
Anne Christine Bay-Jensen<br />
In review in Proteome Science<br />
The industrial PhD project has been supported by the Ministry <strong>of</strong> Science, Technology and<br />
Innovation (VTU) (08-036109) and Nordic Bioscience A/S.<br />
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