CHAPTER 2: Introduction Hopefully, future studies may better define the molecular mechanisms <strong>of</strong> GC actions, thus triggering the discovery <strong>of</strong> new GC formulations providing a better pharmacokinetic pr<strong>of</strong>ile and fewer adverse effects. As GCs may be a potential treatment for OA, the effects <strong>of</strong> prednisolone and dexamethasone on <strong>bone</strong> and cartilage cells are investigated in PAPER II 34
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