Identification of important interactions between subchondral bone ...

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Front page pictures Digital drawing of a knee symbolizing pain (http://www.spa-resorts.cz/eng/kaleidoskop/osteoarthritis-treatment-1196.html). Logo from the sponsor of my industrial PhD; The ministry of Science, Technology and Innovation. Logo from the company where I performed my industrial PhD; Nordic Bioscience A/S. Drawing of the three cell types investigated in the present thesis; Osteoclast (red), osteoblast (brawn), and chondrocyte (blue).
Supervisors University of Copenhagen: Supervisors Søren Tvorup Christensen, PhD, Associate Professor Department of Biology Universitetsparken 13 DK-2100 Copenhagen OE stchristensen@bio.ku.dk Nordic Bioscience A/S: Morten Asser Karsdal, PhD, CEO Herlev Hovedgade 207 DK-2730 Herlev mk@nordicbioscience.com Anne-Christine Bay-Jensen, PhD Herlev Hovedgade 207 DK-2730 Herlev acbj@nordicbioscience.com Kim Henriksen, PhD Herlev Hovedgade 207 DK-2730 Herlev kh@nordicbioscience.com 1
Page 1: F A C U L T Y O F S C I E N C E U N
Page 5 and 6: Preface Preface The work presented
Page 7 and 8: Contents Contents Abstract ........
Page 9 and 10: Abstract Abstract Osteoarthritis (O
Page 11 and 12: Sammendrag på dansk Sammendrag på
Page 13 and 14: CHAPTER 1 Objectives CHAPTER 1: Obj
Page 15 and 16: CHAPTER 2 Introduction CHAPTER 2: I
Page 17 and 18: 2.2 Biology of the joint CHAPTER 2:
Page 19 and 20: CHAPTER 2: Introduction Also osteob
Page 21 and 22: CHAPTER 2: Introduction follows nor
Page 23 and 24: CHAPTER 2: Introduction When the jo
Page 25 and 26: CHAPTER 2: Introduction Cartilage i
Page 27 and 28: 2.3 The pathology of Osteoarthritis
Page 29 and 30: CHAPTER 2: Introduction number of a
Page 31 and 32: CHAPTER 2: Introduction Cysteine pr
Page 33 and 34: CHAPTER 2: Introduction include car
Page 35 and 36: 2.4 The effect of Glucocorticoids C
Page 37 and 38: 2.5 References for CHAPTER 2 1 WebM
Page 39 and 40: 51 Lorenz H. and Richter W. Osteoar
Page 41 and 42: 97 Nakamura H., Tanaka M., Masuko-H
Page 43 and 44: 139 Garnero P., Ayral X., Rousseau
Page 45 and 46: CHAPTER 3 Overview of OA models CHA
Page 47 and 48: CHAPTER 3: Overview of OA models of
Page 49 and 50: 3.3 Ex vivo controls CHAPTER 3: Ove
Page 51 and 52: 19 Brandt K.D. Animal models of ost
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CHAPTER 4 CHAPTER 4: PAPER I PAPER
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266 Cartilage 2(3) therapy for oste
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268 Cartilage 2(3) Figure 1. Charac
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270 Cartilage 2(3) Figure 4. The ca
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272 Cartilage 2(3) Figure 5. Cytoki
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274 Cartilage 2(3) Figure 6. The an
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276 Cartilage 2(3) supports the inc
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278 Cartilage 2(3) release and rece
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CHAPTER 5 CHAPTER 5: PAPER II PAPER
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leading to fragility fractures [12]
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after 1 week (Fig. 2F). The additio
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use a range of assays ranging from
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still some controversy regarding th
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CHAPTER 6 CHAPTER 6: PAPER III PAPE
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Biomarkers Downloaded from informah
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CHAPTER 7 CHAPTER 7: PAPER IV PAPER
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Introduction CHAPTER 7: PAPER IV Ca
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Bovine articular cartilage experime
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CHAPTER 7: PAPER IV Detection of ke
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CHAPTER 7: PAPER IV The MMP inhibit
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CHAPTER 7: PAPER IV The pre-stimula
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CHAPTER 8 CHAPTER 8: General discus
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Future perspectives CHAPTER 8: Futu
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Appendix I Co-author declarations f
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Appendix I 107
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Appendix I 109
Page 113 and 114:
Appendix I 111
Page 115:
Biochemical Markers of Joint Tissue
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