Identification of important interactions between subchondral bone ...

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Appendix II Publication list 4 first author papers 11 co-Author papers 1 Submitted (first author) Induction of Increased cAMP Levels in Articular Chondrocytes Blocks Matrix Metalloproteinase– Mediated Cartilage Degradation, but Not Aggrecanase-Mediated Cartilage Degradation Morten Asser Karsdal, Eren Ufuk Sumer, Helle Wulf, Suzi H. Madsen, Claus Christiansen, Amanda J. Fosang, and Bodil-Cecilie Sondergaard. ARTHRITIS & RHEUMATISM, Vol. 56, No. 5, May 2007, pp 1549–1558. Patients with Rheumatoid Arthritis have an altered circulatory Aggrecan Profile Jean Charles Rousseau, Eren U Sumer, Gert Hein, Bodil C Sondergaard, Suzi H. Madsen, Christian Pedersen, Thomas Neumann, Andreas Mueller, Per Qvist, Pierre Delmas and Morten A Karsdal. BMC Musculoskeletal Disorders, 2008 May 28;9:74. Cartilage Degradation is Fully Reversible in the Presence of Aggrecanase but not Matrix Metalloproteinase Activity Morten Karsdal, Suzi Madsen, Eren Sumer, Claus Christensen, Kim Henriksen, Amanda Fosang, Bodil Sondergaard. Arthritis Res Ther. 2008;10(3):R63. Epub 2008 May 30 Cartilage formation measured by a novel PIINP assay suggests that IGF-I does not stimulate but maintains cartilage formation ex vivo Suzi H. Madsen, Sondergaard BC, Jensen AC, Morten A Karsdal. Scand J Rheumatol. 2009 May-Jun;38(3):222-6 Appendix II 112 Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development. Karsdal MA, Henriksen K, Leeming DJ, Mitchell P, Duffin K, Barascuk N, Klickstein L, Aggarwal P, Nemirovskiy O, Byrjalsen I, Qvist P, Bay-Jensen AC, Dam EB, Madsen SH, Christiansen C. Biomarkers. 2009 May;14(3):181-202. Review. Is bone quality associated with collagen age? Leeming DJ, Henriksen K, Byrjalsen I, Qvist P, Madsen SH, Garnero P, Karsdal MA. Osteoporos Int. 2009 Sep;20(9):1461-70. MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation - divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Sondergaard BC, Schultz N, Madsen SH, Bay- Jensen AC, Kassem M, Karsdal MA. Osteoarthritis Cartilage. 2009 Nov 11. [Epub ahead of print] Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments. Wang B, Chen P, Jensen AC, Karsdal MA, Madsen SH, Sondergaard BC, Zheng Q, Qvist P. BMC Res Notes. 2009 Dec 18;2:259.
Biochemical Markers of Joint Tissue Turnover. Bay-Jensen AC, Sondergaard BC, Christiansen C, Karsdal MA, Madsen SH, Qvist P. Assay Drug Dev Technol. 2010 Feb;8(1):118-24 Application of biochemical markers in development of drugs for treatment of osteoarthritis. Qvist P, Christiansen C, Karsdal MA, Madsen SH, Sondergaard BC, Bay-Jensen AC. Biomarkers. 2010 Feb.;15(1):1-19. Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis? Bay-Jensen AC, Hoegh-Madsen S, Dam E, Henriksen K, Sondergaard BC, Pastoureau P, Qvist P, Karsdal MA.. Rheumatol Int. 2010 Feb;30(4):435-42. Aggrecanase- and matrix metalloproteinase- mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo. Madsen SH, Sumer EU, Bay-Jensen AC, Sondergaard BC, Qvist P, Karsdal MA. Biomarkers. 2010 May 15(3):266-76 Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes. Sondergaard BC, Madsen SH, Segovia-Silvestre T, Paulsen SJ, Christiansen T, Pedersen C, Bay-Jensen AC, Karsdal MA. BMC Musculoskelet Disord. 2010 Apr. 5;11:62. Characterization of an ex vivo femoral head model using bone and cartilage turnover. Suzi Hoegh Madsen, Anne Sofie Goettrup, Gedske Thomsen, Søren Tvorup Christensen, Nikolaj Schultz, Kim Henriksen, Anne-Christine Bay-Jensen, Morten Asser Karsdal. Cartilage. 2011 July; vol. 2, 3: pp. 265-278, first published on October 2010. Appendix II 113 Glucocorticoids exert context-dependent effects on cells of the joint in vitro. Suzi Hoegh Madsen, Kim Vietz Andreassen, Søren Tvorup Christensen, Morten Asser Karsdal, Francis Michael Sverdrup, Anne-Christine Bay-Jensen, Kim Henriksen. Steroids. Acceptet, July 2011 Metalloproteinase and cysteine protease profiles in normal and OA cartilage. Suzi Hoegh Madsen, Kim Henriksen, Søren Tvorup Christensen, Morten Asser Karsdal, Anne- Christine Bay-Jensen. Proteome Science. Submitted, September 2011 Acknowledged for creating figures for papers Matrix metalloproteinase and aggrecanase generated aggrecan fragments: implications for the diagnostics and therapeutics of destructive joint diseases. Sumer, E. U., Qvist, P. and Tankó, L. B. Drug Development Research, 2007, 68: 1–13. Post-translational modifications of the extracellular matrix are key events in cancer progression: Opportunities for biochemical marker development. D. J. Leeming, A. C. Bay-Jensen, E. Vassiliadis, M. R. Larsen, K. Henriksen, and M.A. Karsdal. Biomarkers, 2011; 16(3): 193–205.
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F A C U L T Y O F S C I E N C E U N
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Supervisors University of Copenhage
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Preface Preface The work presented
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Contents Contents Abstract ........
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Abstract Abstract Osteoarthritis (O
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Sammendrag på dansk Sammendrag på
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CHAPTER 1 Objectives CHAPTER 1: Obj
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CHAPTER 2 Introduction CHAPTER 2: I
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2.2 Biology of the joint CHAPTER 2:
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CHAPTER 2: Introduction Also osteob
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CHAPTER 2: Introduction follows nor
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CHAPTER 2: Introduction When the jo
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CHAPTER 2: Introduction Cartilage i
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2.3 The pathology of Osteoarthritis
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CHAPTER 2: Introduction number of a
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CHAPTER 2: Introduction Cysteine pr
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CHAPTER 2: Introduction include car
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2.4 The effect of Glucocorticoids C
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2.5 References for CHAPTER 2 1 WebM
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51 Lorenz H. and Richter W. Osteoar
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97 Nakamura H., Tanaka M., Masuko-H
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139 Garnero P., Ayral X., Rousseau
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CHAPTER 3 Overview of OA models CHA
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CHAPTER 3: Overview of OA models of
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3.3 Ex vivo controls CHAPTER 3: Ove
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19 Brandt K.D. Animal models of ost
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CHAPTER 4 CHAPTER 4: PAPER I PAPER
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266 Cartilage 2(3) therapy for oste
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268 Cartilage 2(3) Figure 1. Charac
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270 Cartilage 2(3) Figure 4. The ca
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272 Cartilage 2(3) Figure 5. Cytoki
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