Identification of important interactions between subchondral bone ...
Identification of important interactions between subchondral bone ...
Identification of important interactions between subchondral bone ...
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Abbreviations<br />
Abbreviations<br />
342-G2 MMP-mediated 342 FFGV-G2 fragment from aggrecan<br />
374-G2 Aggrecanase-mediated 374 ARGS-G2 fragment from aggrecan<br />
ADAMTS Aggrecanase/A disintergrin and metalloproteinase with thrombospondin motifs<br />
AGNx-II MMP-mediated 342 FFGV-G2 fragment from aggrecan<br />
ALP Alkaline phosphatase<br />
BMP Bone morphogenetic proteins<br />
CC Chondrocyte<br />
COMP Cartilage oligomeric matrix protein<br />
CIIM Collagen type II<br />
CTX-I C-telopeptide <strong>of</strong> type I collagen<br />
CTX-II C-telopeptide <strong>of</strong> type II collagen<br />
DEX Dexamethasone<br />
DMOADs Disease modifying osteoarthritis drugs<br />
ECM Extra-cellular matrix<br />
ELISA Enzyme-linked Immuno Sorbent Assay<br />
E64 Irreversible inhibitor <strong>of</strong> cysteine proteases<br />
FDA The US Food and Drug Administration<br />
G1, G2, G3 Globular domain-1, -2, and -3<br />
GAG Glycosaminoglycan, a proteoglycan<br />
GC Glucocorticoid<br />
GH Growth hormone<br />
GM6001 General MMP inhibitor<br />
GR Glucocorticoid receptor<br />
HA Hyaluronic acid<br />
IGF Insulin-like growth factor-1<br />
IHC Immunohistochemistry<br />
IL Interleukin<br />
mAb Monoclonal antibody<br />
M-CSF Macrophage - colony stimulating factor<br />
MMP Matrix metalloproteinase<br />
MRI Magnetic resonance imaging<br />
NSAIDs Non-steroidal anti-inflammatory drugs<br />
OA Osteoarthritis<br />
OB Osteoblast<br />
OC Osteoclast<br />
ON Overnight<br />
OPG Osteoprotegerin<br />
OSM Oncostatin M<br />
OVX Ovariectomy<br />
PBS Phosphate buffered saline<br />
PICP C-terminal propeptide <strong>of</strong> type I procollagen<br />
PIIANP N-terminal propeptide <strong>of</strong> type II procollagen, splice variant A<br />
PIINP N-terminal propeptide <strong>of</strong> type II procollagen<br />
PINP N-terminal propeptide <strong>of</strong> type I procollagen<br />
PRED Prednisolone<br />
PTH Parathyroid hormone<br />
RA Rheumatoid arthritis<br />
RANK Receptor activator <strong>of</strong> nuclear factor-ĸβ<br />
RANKL Receptor activator <strong>of</strong> nuclear factor-ĸβ ligand<br />
sGAG Sulfated glycosaminoglycans<br />
SD Standard deviation<br />
TGF-β Transforming growth factor β<br />
TIMP Tissue inhibitor <strong>of</strong> metalloproteinase<br />
TNF-α Tumour necrosis factor-α<br />
TRAP Tartrate resistant acid phosphatase<br />
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