Identification of important interactions between subchondral bone ...

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Abbreviations Abbreviations 342-G2 MMP-mediated 342 FFGV-G2 fragment from aggrecan 374-G2 Aggrecanase-mediated 374 ARGS-G2 fragment from aggrecan ADAMTS Aggrecanase/A disintergrin and metalloproteinase with thrombospondin motifs AGNx-II MMP-mediated 342 FFGV-G2 fragment from aggrecan ALP Alkaline phosphatase BMP Bone morphogenetic proteins CC Chondrocyte COMP Cartilage oligomeric matrix protein CIIM Collagen type II CTX-I C-telopeptide of type I collagen CTX-II C-telopeptide of type II collagen DEX Dexamethasone DMOADs Disease modifying osteoarthritis drugs ECM Extra-cellular matrix ELISA Enzyme-linked Immuno Sorbent Assay E64 Irreversible inhibitor of cysteine proteases FDA The US Food and Drug Administration G1, G2, G3 Globular domain-1, -2, and -3 GAG Glycosaminoglycan, a proteoglycan GC Glucocorticoid GH Growth hormone GM6001 General MMP inhibitor GR Glucocorticoid receptor HA Hyaluronic acid IGF Insulin-like growth factor-1 IHC Immunohistochemistry IL Interleukin mAb Monoclonal antibody M-CSF Macrophage - colony stimulating factor MMP Matrix metalloproteinase MRI Magnetic resonance imaging NSAIDs Non-steroidal anti-inflammatory drugs OA Osteoarthritis OB Osteoblast OC Osteoclast ON Overnight OPG Osteoprotegerin OSM Oncostatin M OVX Ovariectomy PBS Phosphate buffered saline PICP C-terminal propeptide of type I procollagen PIIANP N-terminal propeptide of type II procollagen, splice variant A PIINP N-terminal propeptide of type II procollagen PINP N-terminal propeptide of type I procollagen PRED Prednisolone PTH Parathyroid hormone RA Rheumatoid arthritis RANK Receptor activator of nuclear factor-ĸβ RANKL Receptor activator of nuclear factor-ĸβ ligand sGAG Sulfated glycosaminoglycans SD Standard deviation TGF-β Transforming growth factor β TIMP Tissue inhibitor of metalloproteinase TNF-α Tumour necrosis factor-α TRAP Tartrate resistant acid phosphatase 104
Appendix I Co-author declarations for paper I - IV Appendix I 105
Page 1 and 2:
F A C U L T Y O F S C I E N C E U N
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Supervisors University of Copenhage
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Preface Preface The work presented
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Contents Contents Abstract ........
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Abstract Abstract Osteoarthritis (O
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Sammendrag på dansk Sammendrag på
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CHAPTER 1 Objectives CHAPTER 1: Obj
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CHAPTER 2 Introduction CHAPTER 2: I
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2.2 Biology of the joint CHAPTER 2:
Page 19 and 20:
CHAPTER 2: Introduction Also osteob
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CHAPTER 2: Introduction follows nor
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CHAPTER 2: Introduction When the jo
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CHAPTER 2: Introduction Cartilage i
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2.3 The pathology of Osteoarthritis
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CHAPTER 2: Introduction number of a
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CHAPTER 2: Introduction Cysteine pr
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CHAPTER 2: Introduction include car
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2.4 The effect of Glucocorticoids C
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2.5 References for CHAPTER 2 1 WebM
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51 Lorenz H. and Richter W. Osteoar
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97 Nakamura H., Tanaka M., Masuko-H
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139 Garnero P., Ayral X., Rousseau
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CHAPTER 3 Overview of OA models CHA
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CHAPTER 3: Overview of OA models of
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3.3 Ex vivo controls CHAPTER 3: Ove
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19 Brandt K.D. Animal models of ost
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CHAPTER 4 CHAPTER 4: PAPER I PAPER
Page 55 and 56: 266 Cartilage 2(3) therapy for oste
Page 57 and 58: 268 Cartilage 2(3) Figure 1. Charac
Page 59 and 60: 270 Cartilage 2(3) Figure 4. The ca
Page 61 and 62: 272 Cartilage 2(3) Figure 5. Cytoki
Page 63 and 64: 274 Cartilage 2(3) Figure 6. The an
Page 65 and 66: 276 Cartilage 2(3) supports the inc
Page 67 and 68: 278 Cartilage 2(3) release and rece
Page 69 and 70: CHAPTER 5 CHAPTER 5: PAPER II PAPER
Page 71 and 72: leading to fragility fractures [12]
Page 73 and 74: after 1 week (Fig. 2F). The additio
Page 75 and 76: use a range of assays ranging from
Page 77 and 78: still some controversy regarding th
Page 79 and 80: CHAPTER 6 CHAPTER 6: PAPER III PAPE
Page 81 and 82: Biomarkers Downloaded from informah
Page 91 and 92: CHAPTER 7 CHAPTER 7: PAPER IV PAPER
Page 93 and 94: Introduction CHAPTER 7: PAPER IV Ca
Page 95 and 96: Bovine articular cartilage experime
Page 97 and 98: CHAPTER 7: PAPER IV Detection of ke
Page 99 and 100: CHAPTER 7: PAPER IV The MMP inhibit
Page 101 and 102: CHAPTER 7: PAPER IV The pre-stimula
Page 103 and 104: CHAPTER 8 CHAPTER 8: General discus
Page 105: Future perspectives CHAPTER 8: Futu
Page 109 and 110: Appendix I 107
Page 115: Biochemical Markers of Joint Tissue
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