Untitled - D Ank Unlimited

apoptosis 73 apoptosis
Removal of a cytokine required for cellular viability leads to the following sequential events: (1) loss of kinase (AKT) activity; (2) dephosphorylation of
Bad (or some other regulator of Bcl-2/Bcl-x activity); (3) Bad binding to Bcl-2; (4) loss of normal mitochondrial physiology; (5) release of cytochrome c;
(6) binding of cytochrome c by Apaf-1 with concomitant activation of caspase 9; (7) amplification by the caspase cascade; (8) cleavage of vital cellular
proteins; (9) fission of cells into apoptotic bodies; and finally (10) disappearance of any trace of the cell when the apoptotic bodies are engulfed by either
neighboring or phagocytic cells.
A