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antiprogesterone receptor antibody 68 antiserum
Anti-PM/Scl autoantibodies.
specific for a complex of nucleolar proteins, the principal
antigen having a mass of 100 kDa, and is found mainly in
Caucasian patients with overlap syndrome.
antiprogesterone receptor antibody
A mouse monoclonal antibody against human progesterone
receptor; a mouse monoclonal anti-human progesterone
receptor antibody that specifically recognizes the A and B
forms of the receptor in Western blot purified recombinant
receptor, normal endometrium, and cell lysates of the progesterone
receptor-rich T47D human breast carcinoma cell
line. No reactivity was observed with lysate of the progesterone
receptor-negative MDA-MB-231 breast carcinoma
cells. No crossreactivity was found with androgen receptor,
estrogen receptor, or glucocorticoid receptor. The antibody
binds an epitope found between amino acids 165 and 534,
in the N terminal transactivation domain of the progesterone
receptor molecule. Various tumors of the female
reproductive tract have been shown to express progesterone
receptor. Immunoreactivity has been demonstrated in breast
carcinoma, uterine papillary serous carcinoma, endometrial
carcinoma, ovarian serous borderline tumor, endometrial
stromal sarcoma, uterine adenomatoid tumor, and ovarian
thecoma. Other tumors shown to stain positively include
medullary carcinoma of the thyroid and meningioma.
antiprolactin antibody
A rabbit antibody that gives positive staining of the prolactin
cells of the anterior pituitary and benign and malignant
neoplasms derived from these cells.
antiprostate-specific antigen antibody
A rabbit antibody that reacts with prostatic ductal epithelial
cells: normal, benign hypertrophic, and neoplastic. It labels the
cytoplasm of prostatic epithelium, secretions, and concretions.
anti-Purkinje cell antibody
An antibody detected in the circulation of patients with
subacute cerebellar degeneration and in those with ovarian
neoplasms and other gynecologic malignancies.
anti-RA-33 antibodies
Antibodies considered specific for rheumatoid arthritis
(RA) have now been found in other autoimmune diseases
and are detected by immunoblotting.
antiretroviral drugs
Therapeutic agents employed to inhibit replication and
spread of HIV. They include protease inhibitors, nucleoside
and non-nucleoside reverse transcriptase inhibitors, and
fusion inhibitors that block fusion of the HIV viral envelope
to the host cell membrane.
anti-Ri antibody
An antibody found in sera and spinal fluids of patients with
opsoclonus without myoclonus that occurs in conjunction
with gait ataxia in women with breast cancer. The anti-Ri
antibody reacts with 55- and 80-kDa proteins present in the
nuclei of central nervous system neurons and breast tumor
cells. The condition may remit, manifest exacerbations and
remissions, and occasionally respond to steroids or other
immune interventions.
Antiribosomal RNP autoantibodies.
antiribosomal rRNP antibodies
Antibodies that react with ribosomal phosphoproteins P1
and P2. Anti-P is present in 10% of systemic lupus erythematosus
(SLE) patients.
anti-scRNP (Ro-SS-A, La-SS-B)
Anti-La-SS-B antibodies are found mainly in patients with
Sjögren’s syndrome but also in those with systemic lupus
erythematosus (SLE) and rheumatoid arthritis (RA). These
antibodies are usually found together with anti-Ro-SS-A.
Anti-Ro-SS-A frequently occurs alone in SLE and systemic
sclerosis. There is no correlation between anti-Ro-SS-A and
anti-La-SS-B antibody in patients with SLE and disease
activity. Maternal anti-Ro-SS-A is the greatest single risk
factor for the development of intrauterine or neonatal complete
heart block in a child.
antisense oligonucleotide
An oligonucleotide created to interfere with the synthesis of
a human protein by binding specifically to a complementary
sequence, the “sense strand” in a primary RNA transcript
or mRNA that encodes the protein concerned. The resulting
duplex mRNA may inhibit the splicing of the primary
transcript, stop mRNA translation, interfere with ribosomal
assembly, or lead to cleavage of mRNA by RNase H activation.
antiseptic paint
A colloquial designation for the coating effect of secretory
immunoglobulin A (IgA), such as that produced locally in the
gut, on mucosal surfaces, thereby barring antigen access.
antiserum
A preparation of serum containing antibodies specific
for a particular antigen (i.e., immunogen). A therapeutic
antiserum may contain antitoxin, antilymphocyte antibodies,
etc. An antiserum contains a heterogeneous collection
of antibodies that bind the antigen used for immunization.
Each antibody has a specific structure, antigenic specificity,
and crossreactivity contributing to the heterogeneity that
renders an antiserum unique.