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Untitled - D Ank Unlimited

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X-linked severe combined immunodeficiency (XSCID) 755 XYZ cell theory (historical)<br />

be caused by an inability to combat Epstein–Barr virus,<br />

leading to a fatal outcome.<br />

X-linked severe combined immunodeficiency (XSCID)<br />

A condition characterized by T cell development failure<br />

during an early intrathymic stage, resulting in a lack of production<br />

of mature T cells or T cell-dependent antibody. It is<br />

a consequence of a defect in a gene that encodes portions of<br />

receptors for different cytokines such as inherited mutations<br />

in the common γ chains of the receptors for interleukin-2<br />

(IL2), IL4, IL7, IL9, and IL15, resulting in impaired ability<br />

to transmit signals from the receptor to intracellular proteins.<br />

x-ray crystallography<br />

A method to analyze protein structure at the atomic<br />

level. Monochromatic X-rays from a rotating anode<br />

x-ray generator or a synchrotron are directed to bombard<br />

a crystallized protein. Although most x-rays pass<br />

through the crystal, some are deflected after striking<br />

atoms of the protein to produce a detectable and<br />

reproducible pattern. Analysis of the diffraction reveals<br />

information about the positions and orientations of the<br />

atoms in the crystal.<br />

XYZ cell theory (historical)<br />

An earlier concept of antibody synthesis proposing (1) an<br />

immunocompetent X cell that had not participated previously<br />

in a specific immune response, (2) a Y cell activated<br />

immunologically by X cell interaction with antigen, and<br />

(3) a Z cell that synthesized antibodies following second<br />

contact with antigen.<br />

X

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