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Wu–Kabat plot 752 W, X, Y boxes (MHC class II promoter)
Worms.
Almroth Edward Wright.
system. He studied immunology in Frankfurt-am-Main
under Paul Ehrlich and made important contributions to the
immunology of infectious diseases and immunization. He
played a significant role in the founding of the American
Association of Immunologists. His published works include
Pathology and Treatment of War Wounds, 1942; Researches
in Clinical Physiology, 1943; and Studies in Immunology
(2 volumes), 1944.
Wu–Kabat plot
A graph that demonstrates the extent of variability at
individual amino acid residue positions in immunoglobulin
and T cell receptor (TCR) variable regions. Division of the
different amino acid numbers at a given position by the
frequency of the amino acid that occurs most commonly at
that position gives the index of variability (from 1 to 400).
To show the variability graphically, a biograph is prepared
in which the index is plotted at each residue position. This
plot indicates the extent of variability at each position and
Variability Index
4000
3000
2000
1000
rms
0
1
0
Variability of TCR β chains. Variability indices calculated according to the
modified formula are plotted for the 159 TCR β chains from database 1.
Wu-Kabat plot.
is useful in localizing immunoglobulin and TCR hypervariable
regions. This analytic method revealed that the most
variable residues of immunoglobulin heavy or light chains
are clustered in three hypervariable regions.
W, X, Y boxes (MHC class II promoter)
Three conserved sequences found in the promoter region
of the HLA-DRα chain gene. The X box contains tandem
regulatory sequences designated X1 and X2. Any cell
that expresses major histocompatibility complex (MHC)
class II molecules will have all three boxes interacting with
binding proteins. Decreased or defective production of
some of these binding proteins can lead to bare lymphocyte
syndrome.