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V(J) recombination 745 von Krough equation
NH 2
Somatomedin
B domain
Cell attachment
region
RGD
= Cysteine residues
Connector
domain
cells by insertion of soluble C5b67 complexes from other cell
surfaces. Also called epibolin and protein S.
V(J) recombination
Class switching.
Vκ
The variable region of an immunoglobulin κ light chain.
This symbol may be used to signify the part of a variable
region encoded by the Vκ gene segment.
Vλ
The variable region of an immunoglobulin λ light chain.
The symbol may designate the part of a variable region
encoded by the Vλ gene segment.
VLA-4
An integrin molecule found on T lymphocyte surfaces that
binds to mucosal cell adhesion molecules.
VLA receptors
A family of integrin receptors found on cell surfaces.
They consist of α and β transmembrane chain heterodimers.
VLA-binding sites are located at the Arg–Gly–Asp
sequences of vitronectin and fibronectin. VLA receptors
occur principally on T lymphocytes. They also bind laminin
and collagen and participate in cell–extracellular matrix
interactions.
VLIA (virus-like infectious agent)
A mycoplasma, possibly synergistic with HIV-1, leading to
profound immunodeficiency, named Mycoplasma incognitos.
V L region
The variable region of an immunoglobulin light chain. The
symbol may be used to designate the segment encoded by
the VL gene.
v-myb oncogene
A genetic component of an acute transforming retrovirus
that leads to avian myeloblastosis. It represents a truncated
genetic form of c-myb.
Vogt–Koyanagi–Harada (VKH) syndrome
Uveal inflammation with acute iridocyclitis, choroiditis, and
retinal detachment. Initial manifestations include headache,
dysacusis, and sometimes vertigo. Scalp hair may show
patchy loss or whitening. Vitiligo and poliosis occur often.
The development of delayed-type hypersensitivity to melanin-containing
tissue has been postulated. Apparently, pigmented
constituents of the eye, hair, and skin are altered by
some type of insult in a manner that leads to a delayed-type
hypersensitivity response. Possible autoantigens are soluble
substances from the retinal photoreceptor layer. Uveal tissue
extracts have been used in delayed-hypersensitivity skin
tests. Antibodies to uveal antigens may be present, but they
are not specific for VKH. Hereditary factors play a predisposing
role. Asians have a predisposition to VKH, a common
cause of uveitis in Japan. VKH syndrome is closely
1 2 3
Vitronectin.
Heparin binding
region
1 2 3 4
Hemopexin domains
10K
COOH
Hematoxylin and eosin (H&E) stained eye section showing extensive
mononuclear cellular infiltrate of lymphocytes and plasma cells.
Vogt–Koyanagi–Harada (VKH) funduscopic examination reveals venous
engorgement and serous retinal detachment.
associated with HLA-DR4. Corticosteroids, chlorambucil,
cyclophosphamide, and cyclosporin A have been used for
treatment.
Vollmer test (historical)
A tuberculin patch test employing gauze treated with
tuberculin.
voltage-gated calcium channel autoantibodies
Autoantibodies specific for voltage-gated calcium channels
(VGCCs) located on presynaptic nerve terminals are
generated during an autoimmune disease associated with
small cell lung cancer (SCLC) known as Lambert–Eaton
myasthenic syndrome (LEMS). Although the exact role of
N-type VGCC autoantibodies remains to be determined,
they may contribute to disturbance of autonomic neurotransmitter
release associated with LEMS.
von Krough equation
A mathematical equation to ascertain serum hemolytic
complement titer. It correlates complement with the extent
V