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anti-human cytokeratin 7 antibody 60 anti-human gastrin antibody
and malignant epithelial cell lines. Because specific combinations
of cytokeratin peptides are associated with different
epithelial cells, these peptides are clinically important
markers for classifying carcinomas (tumors of epithelial
origin) and for distinguishing carcinomas from malignant
tumors of nonepithelial origin such as lymphomas, melanomas,
and sarcomas. The identification of cytokeratin has
gained increasing importance in immunopathology.
Cytokeratin 7⎯adenocarcinoma of the lung.
anti-human cytokeratin 7 antibody
A mouse monoclonal antibody directed against the 54-kDa
cytokeratin intermediate filament protein identified as
cytokeratin 7, a basic cytokeratin found in most glandular
epithelia and in transitional epithelia. The antibody reacts
with a large number of epithelial cell types including many
ductal and glandular epithelia. In general, the antibody does
not react with stratified squamous epithelia but is reactive
with transitional epithelium of the urinary tract. The
antibody reacts with many benign and malignant epithelial
lesions. Keratin 7 is expressed in specific subtypes of
adenocarcinomas from ovary, breast, and lung, whereas
carcinomas from the gastrointestinal tract remain negative.
Transitional cell carcinomas express keratin 7, whereas prostate
cancer is generally negative. The antibody does not react
with squamous cell carcinomas, rendering it a rather specific
marker for adenocarcinoma and transitional cell carcinoma.
In cytological specimens, the antibody permits ovarian
carcinoma to be distinguished from colon carcinoma.
anti-human cytokeratin 20 antibody
A mouse monoclonal antibody that reacts with the 46-kDa
cytokeratin intermediate filament protein. It reacts with intestinal
epithelium, gastric foveolar epithelium, and a number of
endocrine cells of the upper portions of the pyloric glands, as
well as with the urothelium and Merkel’s cells in the epidermis.
The antibody has been tested on a series of carcinomas,
including primary and metastatic lesions. There is a marked
difference in expression of cytokeratin 20 among various
carcinoma types. Neoplasia expressing cytokeratin 20 are
derived from normal epithelia expressing cytokeratin 20.
Colorectal carcinomas consistently express cytokeratin 20,
whereas adenocarcinomas of the stomach express cytokeratin
Cytokeratin 20⎯adenoma of the colon.
20 to a lesser degree. Adenocarcinomas of the gall bladder
and bile ducts, ductal cell adenocarcinomas of the pancreas,
mucinous ovarian tumors, and transitional cell carcinomas
have been found to stain positively with the antibody. Most
of the carcinomas from other sites are not positive using the
antibody to cytokeratin 20 (e.g., adenocarcinomas of the
breast, lung, and endometrium and nonmucinous tumors of
the ovary). Merkel cell carcinomas of the skin stain normally
with the anti-cytokeratin 20 antibody. There is a lack of
positivity in small-cell lung carcinomas and in intestinal and
pancreatic neuroendocrine tumor cells.
Follicle-stimulating hormone (FSH)⎯pituitary.
anti-human follicle-stimulating hormone (FSH) antibody
A rabbit antibody that labels gonadotropic cells in the pituitary.
Positive staining for adenohypophyseal hormones assists in the
classification of pituitary tumors. FSH is an adenohypophyseal
glycoprotein hormone found in gonadotropic cells of the
anterior pituitary glands of most mammals. Gonadotropic cells
average about 10% of anterior pituitary cells. This antibody can
be used for immunohistochemical staining.
anti-human gastrin antibody
A rabbit antibody that labels G cells of antropyloric mucosa
of the stomach. It permits immunohistochemical detection
of gastrin-secreting tumors and G cell hyperplasia.