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antigrowth hormone (GH) antibody 59 anti-human cytokeratin (CAM 5.2) antibody
antigrowth hormone (GH) antibody
A rabbit polyclonal antibody against human growth hormone
that positively stains the growth hormone-producing
cells and somatotrophs of the pituitary gland and malignant
and benign neoplasms arising from these cells.
antiheat shock protein antibodies
Heat shock proteins (hsps) have a broad phylogenetic
distribution and share sequence similarities in molecules
derived from bacteria, humans, or other animals. They play
a significant role in inflammation. Heat shock proteins of
mycobacteria are important in the induction of adjuvant
arthritis by these microorganisms. Forty percent of SLE
patients and 10 to 20% of RA patients have antibodies of
IgM, IgG, and IgA classes to a 73-kDa protein of the hsp70
group. RA synovial fluid contains T lymphocytes that react
with a 65-kDa mycobacterial heat shock protein. The significance
of these observations of immune reactivity to heat
shock proteins remains to be determined.
antihepatitis B virus core antigen (HBcAg) antibody
HBcAg is expressed predominantly in the nuclei of infected
liver cells, although variable staining may also be seen in
the perinuclear cytoplasm. This antibody labels the nuclei
and occasionally cytoplasm of virus-infected cells.
antihigh molecular weight human cytokeratin antibodies
Mouse monoclonal antibodies that identify keratins of
approximately 66 and 57 kDa in extracts of the stratum
corneum. The antibody labels squamous, ductal, and other
complex epithelia. It is reactive with both squamous and
ductal neoplasms and variably with those derived from
simple epithelium. Consistently positive are squamous cell
carcinomas, ductal carcinomas (most notably those of the
breast, pancreas, bile duct, and salivary gland), transitional
cell carcinomas of the bladder and nasopharynx, thymomas,
and epithelioid mesotheliomas. Adenocarcinomas
are variably positive. The antibodies are largely unreactive
with adenomas of endocrine organs, carcinomas of the
liver (hepatocellular carcinoma), endometrium, and kidney.
Mesnchymal tumors, lymphomas, melanomas, neural
tumors, and neuroendocrine tumors are unreactive.
antihistamine
A substance that links to histamine receptors, thereby
inhibiting histamine action. Antihistamine drugs derived
from ethylamine block H1 histamine receptors, whereas
those derived from thiourea block the H2 variety.
Antihistone (H2A and H2B) complex autoantibodies.
antihistone antibodies
Antibodies associated with several autoimmune diseases
that include systemic lupus erythematosus (SLE),
drug-induced lupus, juvenile rheumatoid arthritis, and rheumatoid
arthritis. H-1 antibodies are the most common in
SLE followed by anti-H2B, anti-H2A, anti-H3, and anti-H4,
respectively. Antihistone antibodies are usually assayed by
the ELISA technique.
anti-Hu antibodies
Autoantibodies associated with paraneoplastic encephalomyeloneuronitis
(PEMN). They react with neuronal nuclei,
recognizing 35- to 40-kDa antigens present in neuronal
nuclei and also detectable in the nuclei of cells from small
cell carcinoma of the lung. The antibody may be responsible
for the death of neurons.
anti-human -smooth muscle actin
A mouse monoclonal antibody that reacts with the
α-smooth muscle isoform of actin. It reacts with smooth
muscle cells of vessels and different parenchyma without
exception, but with different intensity, according to the
amount of α-smooth muscle actin present in smooth muscle
cells, myoepithelial cells, pericytes, and some stromal cells
in the intestine, testes, breast, and ovary. The antibody also
reacts with myofibroblasts in benign and reactive fibroblastic
lesions and perisinusoidal cells of normal and diseased
human livers.
anti-human chorionic gonadotropin (HCG) antibody
An antibody that reacts with the β chain of human
chorionic gonadotropin (HCG). HCG is a polypeptide
hormone synthesized in the syncytiotrophoblastic cells of
the placenta and in certain trophoblastic tumors. HCG is a
marker for the biochemical differentiation of trophoblastic
cells that often precedes their morphological differentiation.
The antibody aids in the detection of HCG in trophoblastic
elements of germ cell tumors of the ovaries, testes, and
extragonadal sites. It crossreacts with luteinizing hormone.
Cytokeratin 18⎯salivary gland.
anti-human cytokeratin (CAM 5.2) antibody
Monoclonal antibody against cytokeratins, which are
polypeptide chains that form structural proteins within the
epithelial cell cytoskeleton. Nineteen different molecular
forms of cytokeratins have been identified in both normal
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