Untitled - D Ank Unlimited

translocation 716 trastuzumab
translocation
A chromosomal aberration in which one segment of a chromosome
has become joined to another chromosome. B and
T cell rearranging genes are frequently sites of translocation
in B cell and T cell tumors.
transmissible spongiform encephalopathy (TSE)
immunity
Paradoxically, a functional immune system is requisite
for efficient experimental transmission of scrapie and
for TDE agents to pass from one species to another.
Immunologically immature mice are less susceptible to
scrapie than older mice; SCID mice are refractory to infection.
PHA and BCG increase susceptibility to infection.
Interferon, antilymphocyte serum, neonatal thymectomy,
and whole body radiation fail to alter the incubation period.
transplant rejection
Refer to transplantation rejection.
transplantation
The replacement of an organ or other tissue such as bone
marrow with organs or tissues derived ordinarily from a
nonself source such as an allogeneic donor. Organs include
kidney, liver, heart, lung, pancreas (including pancreatic
islets), intestine, and skin. Bone matrix and cardiac valves
have also been transplanted. Bone marrow transplants are
used for nonmalignant conditions such as aplastic anemia
and to treat certain leukemias and other malignant diseases.
transplantation antigens
Histocompatibility antigens that stimulate an immune
response in the recipient that may lead to rejection.
transplantation immunology
The study of immunologic reactivity of a recipient to transplanted
organs or tissues from a histoincompatible recipient.
Effector mechanisms of transplantation rejection and
transplantation immunity consist of cell-mediated immunity
and/or humoral antibody immunity, depending on the
category of rejection. For example, hyperacute rejection of
an organ such as a renal allograft is mediated by preformed
antibodies and occurs soon after the vascular anastomosis is
Kidney cells
ANTIGEN
SENSITIZED LYMPHOCYTES
completed. By contrast, acute allograft rejection is mediated
principally by T lymphocytes and occurs during the first
week after transplantation. There are instances of humoral
vascular rejection mediated by antibodies as a part of the
acute rejection in response. Chronic rejection is mediated
by a cellular response.
transplantation rejection
The consequences of cellular and humoral immune
responses to a transplanted organ or tissue that may lead to
loss of function and necessitate removal of the transplanted
organ or tissue. Transplantation rejection episodes occur
in many transplant recipients but are controlled by such
immunosuppressive drugs as cyclosporine, rapamycin, and
FK506 or by monoclonal antibodies against T lymphocytes.
transport piece
Refer to secretory piece.
transporter associated with antigen processing (TAP)
A TAP-binding heterodimeric protein in the rough endoplasmic
reticulum membrane that transports peptides from
the cytosol to the endoplasmic reticulum lumen. It is comprised
of TAP 1 and TAP 2 subunits that bind peptides to
major histocompatibility complex (MHC) class I molecules.
Genes in the MHC class II region must be expressed for
MHC class I molecules to be assembled efficiently. TAP 1
and 2 are postulated to encode components of a heterodimeric
protein pump that conveys cytosolic peptides to the
endoplasmic reticulum. They associate with MHC class I
heavy chains.
transudation
The movement of electrolytes, fluid, and proteins of low
molecular weight from intravascular spaces to extravascular
spaces as in inflammation.
trastuzumab
A recombinant DNA-derived humanized monoclonal antibody
that selectively binds with high affinity in a cell-based
assay to the extracellular domain of the human epidermal
growth factor receptor 2 protein (HER-2/neu). The antibody
is an IgG 1κ that contains human framework regions with the
ANTIBODY MOLECULES
Rejection.
T cell
Plasma
cell
LYMPH NODE