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antigenic gain 56 antigenic peptide
Drift
Shift
Conformational Determinant
Linear Determinant
Neoantigenic Determinant
N
Antigenic drift and shift.
Accessible
determinant
C
Denaturation
Denaturation
Inaccessible
determinant
Proteolysis
Denaturation
N
C
N
Antigenic determinant.
N
C
Determinant Lost
N
C
N
C
especially in influenza A subtypes that are made up of H1,
H2, and H3 hemagglutinins and N1 and N2 neuraminidases.
Antigenic shifts follow point mutations of DNA
encoding these hemagglutinins and neuraminidases.
antigenic gain
Nondistinctive normal tissue components that are added or
increased without simultaneous deletion of other normal
tissue constituents.
antigenic modulation
The loss of epitopes or antigenic determinants from a
cell surface following combination with an antibody. The
antibodies cause the epitope to disappear or become camouflaged
by covering it.
antigenic mosaicism
Antigenic variation first discovered in pathogenic Neisseria.
It is the result of genetic transformation between gonococcal
strains. It is also observed in penicillin resistance of several
bacterial species when the resistant organism contains
DNA from a host commensal organism.
antigenic peptide
A peptide that is able to induce an immune response and
one that complexes with major histocompatibility complex
(MHC), thereby permitting its recognition by a T cell receptor.
C
Ig binds to
determinant in
native and
denatured protein
Ig binds to
determinant in
denatured protein
only
New determinant