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theliolymphocyte 694 thorotrast (thorium dioxide 32THOT)<br />

theliolymphocyte<br />

A small intraepithelial lymphocyte associated with intestinal<br />

epithelial cells.<br />

Argyrios N. Theofilopoulos.<br />

Argyrios N. Theofilopoulos<br />

Authority on autoimmunity at Scripps Research Institute,<br />

LaJolla, California.<br />

theophylline (1,3,dimethylxanthine)<br />

A compound used to treat acute bronchial asthma<br />

because of its powerful smooth muscle relaxing activity.<br />

Aminophylline, a salt of theophylline, is another smooth<br />

muscle relaxant used to induce bronchodilation in the treatment<br />

of asthma.<br />

therapeutic antisera<br />

Serum antibody preparations employed to protect against<br />

or treat disease. They are distinct from antibody or antisera<br />

preparations used for the serological identification of microorganisms.<br />

Therapeutic antisera such as horse antitoxins against<br />

diphtheria were widely used early in the 20th century. A few<br />

specific antisera such as tetanus antitoxin are still used.<br />

therapeutic vaccination<br />

A vaccine administered to alleviate a pre-existing allergic<br />

or autoimmune condition, cancer, or other disease.<br />

Thermoactinomyces species<br />

Gram-positive, endospore-forming microorganisms that<br />

Aspergillus fumigatus, are the most common causes of the<br />

hypersensitivity pneumonitis (HP) known as farmer’s lung<br />

(FL). Other thermophilic actinomycetes also play a role in<br />

the pathogenesis of this disease. Antibodies reactive with<br />

a 55-kDa band are frequent in the sera of patients with FL,<br />

but the significance is not known.<br />

Thomas, Edward Donnall (1920–)<br />

American hematologist whose fundamental investigations<br />

of bone marrow transplantation led to his winning a Nobel<br />

Prize for Medicine or Physiology with J. E. Murray in<br />

1990.<br />

thoracic duct<br />

A canal that leads from the cisterna chyli, a dilated segment<br />

of the thoracic duct at its site of origin in the lumbar region,<br />

to the left subclavian vein.<br />

thoracic duct drainage<br />

The deliberate removal of lymphocytes through drainage of<br />

lymph from the thoracic duct with a catheter.<br />

E. Donnall Thomas and Joseph E. Murray, recipients of the 1990 Nobel<br />

Prize for Physiology or Medicine for their work during the 1950s and<br />

1960s on reducing the risk of organ rejection by the human immune<br />

system. In 1954, at the Peter Bent Brigham Hospital, Murray performed<br />

the first successful organ transplant of a kidney from one identical twin to<br />

another. Two years later, Thomas performed the first successful transplant<br />

of bone marrow by administering a drug that prevented rejection. Thomas<br />

and Murray made significant discoveries that “enabled the development of<br />

organ and cell transplantation into a method for the treatment of human<br />

disease” (from Nobel Assembly citation).<br />

Lewis Thomas.<br />

Thomas, Lewis<br />

Distinguished American physician who served as Chair of<br />

Pathology at Yale, as administrator at New York University<br />

Medical Center, and as director of Sloan-Kettering-<br />

Memorial Medical Center in New York City. He wrote<br />

popular books on medicine and had a special interest in<br />

tumor immunology.<br />

thorotrast (thorium dioxide 32THOT)<br />

A radiocontrast medium that yields α particles. It is no longer<br />

in use because neoplasia have been attributed to its use.

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