Untitled - D Ank Unlimited

tetanus toxoid 691 Th cells
tetanus toxoid
Formaldehyde-detoxified toxins of Clostridium tetani.
Tetanus toxoid is an immunizing preparation. Individuals
with increased likelihood of developing tetanus as a result of
deep, penetrating wounds caused by rusty nails or other contaminated
objects are immunized by subcutaneous inoculation.
The preparation is available in fluid and adsorbed forms.
It is included with diphtheria toxoid and pertussis vaccine
in a mixture known as DTP, DPT, or triple vaccine. It is
employed to routinely immunize children under 6 years old.
tetanus vaccine
An immunizing preparation to protect against Clostridium
tetani. Refer to DTaP vaccine.
tetramethylrhodamine isothiocyanate
A red fluorochrome used in immunofluorescence.
tetraparental chimera
The deliberate fusion of two-, four-, or eight-cell-stage
murine blastocysts ultimately yields a chimera mouse with
contributions from four parents. These animals are of great
value in studies of immunological tolerance.
tetraparental mouse
An allophenic mouse.
Texas red
A fluorochrome derived from sulforhodamine 101. It is
often used as a second label in fluorescence antibody techniques
where fluorescein, an apple green label, is also used.
This provides two-color fluorescence.
TFA antigens
Antigens in rabbits and rats that result from changes in liver
cell components arising from exposure to the halothane
anesthetic. Rats administered halothane intraperitoneally
expressed maximum amounts of the 100-, 76-, 59-, and
57-kDa antigens after 12 hours. The antigens were still
detectable after 7 days. TFA antigen expression varies in
humans as a consequence of variability of hepatic cytochrome
P-450 isoenzyme profiles.
(TG)AL
Tyrosine and glutamic acid polymers fasten as side chains
to a poly-L-lysine backbone through alanine residues. This
substance is a synthetic antigen.
TGF- (transforming growth factor )
A polypeptide produced by transformed cells. It shares
approximately one third of its 50-amino acid sequence with
epidermal growth factor (EGF). TGF-α has a powerful
stimulatory effect on cell growth and promotes capillary
formation.
TGF- (transforming growth factor )
Five TGF-βs in the C terminal regions of proteins are
structurally similar. They are designated TGF-β 1 through
TGF-β 5 and have similar functions with respect to their
regulation of cellular growth and differentiation. After
formation as secretory precursor polypeptides, TGF-β 1,
TGF-β 2, and TGF-β 3 molecules are altered to form a
25-kDa homodimeric peptide. The ability of TGF-β to
regulate growth depends on the type of cell and whether
other growth factors are also present. TGF-β also regulates
deposition of extracellular matrix and cell attachment to
it. It induces fibronectin, chondroitin/dermatin sulfate proteoglycans,
collagen, and glycosaminoglycans. TGF-β also
promotes the formation and secretion of protease inhibitors.
It has been shown to increase the rate of wound healing and
induce granulation tissue. It also stimulates proliferation of
Human transforming growth factor β 2. Resolution = 1.8 Å.
osteoblasts and chondrocytes. TGF-β inhibits bone marrow
cell proliferation and also blocks interferon-α-induced activation
of natural killer (NK) cells. It diminishes interleukin-2
(IL2) activation of lymphokine-activated killer (LAK)
cells. TGF-β decreases cytokine-induced proliferation of
thymocytes and also decreases IL2-induced proliferation
and activation of mature T lymphocytes. It inhibits T cell
precursor differentiation into cytotoxic T lymphocytes. It
may reverse the activation of macrophages by preventing
the development of cytotoxic activity and superoxide anion
formation necessary for antimicrobial effects. It may also
diminish major histocompatibility complex (MHC) class II
molecule expression and it decreases Fcε receptor expression
in allergic reactions. TGF-β has potential value as an
immunosuppressant in tissue and organ transplantation, and
it may protect bone marrow stem cells from the injurious
effects of chemotherapy. It may have use as an anti-inflammatory
agent based on its ability to inhibit the growth of T
and B cells. It also has potential as a treatment for selected
autoimmune diseases. It diminishes myocardial damage
associated with coronary occlusion, promotes wound
healing, and may be of value in restoring collagen and
promoting formation of bone in patients with osteoporosis.
TGF-β is produced by activated Th2 cells, mononuclear
phagocytes, and other cells. Its main effect is to inhibit proliferation
and differentiation of T cells, inhibit macrophage
activation, and counteract pro-inflammatory cytokines.
TGFs (transforming growth factors)
Polypeptides produced by virus-transformed 3T3 cells that
induce various cells to alter their phenotypes.
T globulin
A serum protein found after hyperimmunization of horses.
It is a γ 1 7S globulin that appears as a prominent band of
immunoglobulin (Ig) when the serum is electrophoresed. It
may be a subtype of IgG.
Th cells
Helper T lymphocytes that identify nonself peptide presented
in the context of MHC class II molecules displayed
T