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T cell receptor (TCR) 685 T cell receptor (TCR)
Subscapsular
large
low density
dividing
spleen seeking
derived from
immature
thymocytes
T 1
3°
1°
Intestine
Peyer’s
Non-Peyer’s
T cell receptor (TCR)
A T cell surface structure composed of a disulfide-linked
heterodimer of highly variable α and β chains expressed at
cell membranes as a complex with invariant CD3 chains.
Most T cells that bear this type of receptor are termed αβ
T cells. A second receptor known as γδ TCR is comprised
of variable γ and δ chains expressed with CD3 on a smaller
subset of T lymphocytes that recognize different types
of antigens. Both types of receptors are expressed with a
disulfide-linked homodimer of ζ chains. Both αβ and γδ
receptors on cell surfaces are associated with complexes of
ZAP-70
s
s
s
s
Lymph node
Migration patterns of thymus cells.
TCR–CD3 complex
α β
s
s
s
s
ε δ γ ε
s
s
s
s
s s
s s
fyn
Antigen
2°
T 2
Deep cortex
small
high density
nondividing
recirculating
derived from
mature
thymocytes
Spleen
Periarteriolar sheath
Marginal zone
Red pulp
invariant CD3 and ζ chains that have a signaling function.
The TCR is a receptor for antigen on CD4 + and CD8 + T
lymphocytes that recognizes foreign peptide–self MHC
molecular complexes on the surfaces of antigen-presenting
cells. In the predominant αβ TCR, each of the two
disulfide-linked transmembrane α and β polypeptide chains
bears one N terminal Ig-like variable (V) domain, one
Ig-like constant (C) domain, a hydrophobic transmembrane
region, and a short cytoplasmic region. Refer also to T
lymphocyte antigen receptor, T cell receptor genes, and T
cell receptor, γδ.
s
s
T cell receptor–CD3 complex.
s
s
CD4
D 1
D 2
D 3
D 4
lck
CD45
T