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tail peptide 680 Tamiflu®
Gaspare Tagliacozzi.
book showed in detail his methods and included illustrations
of his instruments and methods of bandaging. He
drew analogies from the agricultural practices of grafting
in explaining his technique. He understood that xenografts
were impossible and allografts were highly unlikely to
unite, if only because of the awkwardness of keeping the
two parts in close contact so that a graft could take.
tail peptide
An immunoglobulin heavy polypeptide chain carboxyl
terminus separate from the carboxyl terminal domain. Tail
peptides are present in membrane-anchored immunoglobulins.
Tail peptides of 20 amino acids are present in secreted
IgM and IgA molecules. IgG and IgE molecules do not
contain tail peptides.
Takatsy method
A technique that employs tiny spiral loops on the end of a
handle similar to wire loops used by bacteriologists. The
loops are carefully engineered to retain precise volume
when immersed in liquid and are used to prepare doubling
dilutions of test liquids in microtiter wells of test plates. As
the loops are passed from one well to the next, the spiral
motion helps discharge the contents into the well diluent
and mix it. A single operator can manipulate several loops
at one time using a single plastic plate with multiple wells.
This method has been applied to hemagglutination assays.
Takayasu’s arteritis
Inflammation and stenosis involving large- and intermediate-sized
arteries including the aortic arch. The disease
occurs in the 15- to 20-year old age group and exhibits
a 9:1 female predominance. Mononuclear and giant
cells infiltrate all layers of the walls of involved arteries,
reflecting true panarteritis. Intimal proliferation, fibrosis,
elastic lamina disruption, and media vascularization may
be present. The disease begins with an inflammatory phase,
followed within several weeks up to 8 years by a chronic
occlusive phase. In the initial inflammatory phase, patients
develop fever, malaise, weakness, night sweats, arthralgias,
and myalgias. Symptoms in the chronic phase are related
to ischemia of involved organs. Vascular insufficiency is
indicated by decreased or absent radial, ulnar, and carotid
pulses. Approximately one third of the patients may have
cardiac symptoms such as palpitations and congestive heart
failure secondary to hypertension. IgG, IgA, and IgM may
be elevated, and the erythrocyte sedimentation rate is usually
increased. Corticosteroids may be helpful in controlling
inflammation. Cyclophosphamide has been successfully
used in cases not responsive to corticosteroid therapy.
take
The successful grafting of skin that adheres to a recipient
graft site 3 to 5 days following application. This is
accompanied by neovascularization, as indicated by a pink
appearance. Thin grafts are more likely to take than thicker
grafts, but a thin graft must contain some dermis to be successful.
The term take also refers to an organ allotransplant
that has survived hyperacute and chronic rejection.
Norman Talal
Authority on autoimmune diseases, University of Texas,
San Antonio.
Norman Talal.
Talmage, David Wilson (1919–)
American physician and investigator who developed the cell
selection theory of antibody formation in 1956. His work was
a foundation for Burnet’s subsequent clonal selection theory.
After training in immunology with Taliaferro in Chicago,
where he became a professor in 1952, Talmage became the
chairman of microbiology in 1963 and dean of medicine in
1968 at the University of Colorado. He was appointed director
of the Webb–Waring Institute in Denver in 1973. In addition
to his investigations of antibody formation, he studied
heart transplantation tolerance. (Refer to The Chemistry of
Immunity in Health and Disease [with Cann], 1961.)
Tamiflu ®
Refer to oseltamivir.