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smooth muscle antibodies (SMAs) 660 Snell, George Davis (1903–1996)
Lymphatic
system
Vaccination
Lymph node
Theobald Smith.
Antigens
Smooth muscle antibodies (SMAs).
be induced by exposure of the body to chemical substances
or toxins produced by bacteria causing the disease.
smooth muscle antibodies (SMAs)
Autoantibodies belonging to the immunoglobulin M (IgM)
or IgG class found in the sera of 60% of patients with
chronic active hepatitis. Among patients with biliary cirrhosis,
30% may also be positive for these antibodies. Low
Venule
Release of sensitized
lymphocytes into circulation
Delayed
skin
reaction
Smallpox vaccination.
“Take”
Scar
Smooth muscle antibodies (SMAs).
titers of smooth muscle antibodies may be found in certain
viral infections of the liver. The anti-actin variety of smooth
muscle antibodies is especially associated with autoimmune
liver disease, while SMAs directed to intermediate
filaments may appear in virus-induced liver disease. The
presence of SMAs is not predictive of the development of
liver disease and is not helpful for prognosis in autoimmune
patients with chronic active hepatitis.
SNagg
Agglutinating activity by rheumatoid factor in certain normal
sera, as revealed by a positive RA (rheumatoid arthritis) test.
sneaking through
The successful growth of a sparse number of transplantable
tumor cells inoculated into a host in contrast to the induction
of tumor immunity and lack of tumor growth in the
same host if larger doses of the same cells are administered.
Snell–Bagg mice
A mutant strain (dw/dw) of inbred mice with pituitary
dwarfism. Characteristics are a diminutive thymus,
deficient lymphoid tissue, and decreased cell-mediated
immune responsiveness.
Snell, George Davis (1903–1996)
American geneticist who shared the 1980 Nobel Prize
in Medicine or Physiology with Jean Dausset and Baruj
Benacerraf for their work on genetically determined structures
of cell surfaces that regulate immunologic reactions.
Snell’s major contributions were in the field of mouse genetics,
including discovery of the H-2 locus (with Gorer) and