Untitled - D Ank Unlimited

anti-Clq antibody 50 anti-double-stranded DNA (anti-dsDNA)
antibodies. The antibodies do not affect survival and pulmonary
hypertension in patients with limited scleroderma;
however, survival is much longer in anticentromere-positive
patients with limited scleroderma than in anti-Scl-
70-positive diffuse scleroderma patients.
anti-Clq antibody
Present in the majority of patients with hypocomplementemic
urticarial vasculitis syndrome (HUVS) and in 30 to
60% of systemic lupus erythematosus (SLE) patients. Clq
is strikingly decreased in the blood sera of HUVS patients,
even though their Clr and Cls levels are within normal
limits and C5 to C9 are slightly activated.
Cytomegalovirus (CMV)⎯placenta.
anticomplementary
The action of any agent or treatment that interferes with complement
fixation through removal or inactivation of complement
components or cascade reactants. Multiple substances
may exhibit anticomplementary activity. These are especially
significant in complement fixation serology, as anticomplementary
agents may impair the evaluation of test results.
anticytomegalovirus (CMV) antibody
A mouse monoclonal antibody that reacts with CMVinfected
cells giving a nuclear staining pattern with early
antigen and a nuclear and cytoplasmic reaction with the late
viral antigen. The antibody shows no crossreactivity with
other herpesviruses or adenoviruses.
anticytoplasmic antibody
Antineutrophil cytoplasmic antibody occurring in 84 to 100%
of active generalized Wegener’s granulomatosis patients. This
antibody is assayed by flow cytometry and indirect fluorescence
microscopy. HIV-1 infected patients may be biologically
false-positive for neutrophil cytoplasmic antibody.
anti-D antibody
Antibody against the Rh blood group D antigen. This
antibody is stimulated in the RhD – mother by fetal RhD +
red blood cells that enter her circulation at parturition.
Anti-D antibodies become a problem usually with the third
pregnancy, resulting from the booster immune response
against the D antigen to which the mother was previously
exposed. IgG antibodies pass across the placenta, leading to
hemolytic disease of the newborn (erythroblastosis fetalis).
Anti-D antibody (Rhogam ® ) administered up to 72 hours
following parturition may combine with the RhD + red blood
cells in the mother’s circulation, thereby facilitating their
removal by the reticuloendothelial system. This prevents
maternal immunization against the RhD antigen.
Rh D
antigen
Anti-D, IgG
antibodies
+ Complement
“D” red blood cell
RBC
Lysis
Complement-mediated lysis of RhD antigen-positive red blood cells
through doublets of anti-D, IgG antibodies on the red cell surface.
antidesmin antibody
A mouse monoclonal antibody (clone DE-R-11) raised
against purified porcine desmin that reacts with the
53-kDa intermediate filament desmin protein. This
reagent may be used to aid in the identification of cells of
myocyte lineage. The antibody is intended for qualitative
staining in sections of formalin-fixed, paraffin-embedded
tissue. Antidesmin primary antibody specifically binds to
antigens located in the cytoplasm of myocytic cells. The
clinical interpretation of any staining or its absence must
be complemented by morphological studies and evaluation
of proper controls.
anti-DEX antibodies
Murine α1–3 dextran specific antibodies.
Anti-dsDNA (rim pattern).
Anti-dsDNA.
anti-double-stranded DNA (anti-dsDNA)
Antibodies present in the blood sera of systemic lupus erythemastosus
(SLE) patients. Among the detection methods
is an immunofluorescence (IFT) technique using Crithidia
luciliae as the substrate. Fluorescence of the kinetoplast
containing mitochondrial DNA signals the presence of
anti-dsDNA antibodies. This technique is useful for assaying
SLE serum, which is usually positive in patients with active