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S
Abbreviation for sedimentation coefficient.
S antibody
The sedimentation coefficient of immunoglobulin molecules
such as IgG. 6.6S immunoglobulins are usually
referred to as 7S immunoglobulins.
7S antibody
The sedimentation coefficient of immunoglobulin molecules
such as IgG. 6.6S immunoglobulins are usually
referred to as 7S immunoglobulins.
19S antibody
The sedimentation coefficient of the IgM class of
immunoglobulins.
S-100⎯metastatic melanoma, lymph node.
S-100
A heterodimeric protein composed of α and β chains. It is
present in a variety of tissues and is especially prominent
in nervous system tissue including brain, neural crest, and
Schwann cells. It is also positive in breast ducts, sweat and
salivary glands, bronchial glands, serous acini, malignant
melanomas, myoepithelium, and neurofibrosarcomas.
S-100 protein
A marker, demonstrable by immunoperoxidase staining,
that is extensively distributed in both central and peripheral
nervous systems and tumors arising from them, including
astrocytomas, melanomas, Schwannomas, etc. Most melanomas
express S-100 protein. Such non-neuronal cells as
chondrocytes and histiocytes are also S-100-positive.
S-100 protein antibody
A mouse monoclonal antibody specific for S-100 protein
that is found in normal melanocytes, Langerhans cells,
histiocytes, chondrocytes, lipocytes, skeletal and cardiac
muscle, Schwann cells, epithelial and myoepithelial cells
of the breast, salivary and sweat glands, and glial cells.
Neoplasms derived from these cells also express S-100
S
protein, albeit nonuniformly. A large number of well differentiated
tumors of the salivary gland, adipose and cartilaginous
tissue, and Schwann cell-derived tumors express S-100
protein. Most malignant melanomas and cases of histiocytosis
X are positive for S-100 protein. Despite the ubiquity
of S-100 protein, its demonstration is of great value in the
identification of several neoplasms, particularly melanomas.
S protein
A hemolytically active substance encoded by the murine
complement locus C4B.
S region
The chromosomal segment of the murine MHC containing
genes that encode MHC class III molecules including
complement component C2, factor B, C4A (Slp), and C4B
(Ss). The S locus within this region is the site of genes that
encode a 200-kDa protein termed Ss (serum substance)
that corresponds to C4 in human serum. Also within the S
region is the gene for Slp (sex limited protein, usually found
only in male mice), the gene for 21-hydroxylase (an enzyme
with no known immune function), and the gene for a serum
β globulin. The term also refers to the chromosomal segment
between HLA-B and HLA-D where the genes encoding
the corresponding human MHC class III molecules are
situated.
S value (Sverdberg unit)
The sedimentation coefficient of a protein ascertained by
analytical ultracentrifugation.
Albert Sabin.
Sabin, Albert (1906–1993)
American physician and immunologist who developed a
live attenuated oral vaccine for poliomyelitis that produced
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S