Untitled - D Ank Unlimited

anti-CD34 antibody 49 anticentromere antibody
CD34⎯highly vascular tumor.
anti-CD34 antibody
A murine monoclonal antibody raised by immunization
with human placental endothelial cells that has a specificity
for the CD34 glycoprotein, which is considered the earliest
known CD marker and is expressed on virtually all human
hematopoietic progenitor cells.
anti-CD43 antibody
A murine monoclonal antibody directed against an epitope
present on human monocytes, granulocytes, and lymphocytes.
This reagent may be used to aid in the identification
of cells of lymphoid lineage. It is intended for qualitative
staining in sections of formalin-fixed, paraffin-embedded
tissue. Anti-CD43 antibody specifically binds to antigen
located in the plasma membrane and cytoplasmic regions of
normal granulocytes and T lymphocytes.
anti-CD45R (leukocyte common antigen) antibody
A mouse monoclonal antibody specific for an epitope
present on the majority of human leukocytes. This
reagent may be used to aid in the identification of cells
of lymphocytic lineage and is intended for qualitative
staining in sections of formalin-fixed, paraffin-embedded
tissue. It specifically binds to antigens located predominantly
in plasma membranes and to a lesser degree in the
cytoplasma of lymphocytes, with variable reactivity to
monocytes/histiocytes, and polymorphonuclear leukocytes.
Unexpected antigen expression or loss of expression
may occur, especially in neoplasms. Occasional stromal
elements surrounding heavily stained tissues or cells show
immunoreactivity. The clinical interpretation of any staining
or its absence must be complemented by morphological
features and evaluation of proper controls.
anti-CD68 (human macrophage marker) antibody
A murine monoclonal antibody that stains macrophages
and a wide variety of human tissues, including Kupffer’s
cells and macrophages in the red pulp of the spleen, in
the lamina propria of the gut, in lung alveoli, and in bone
marrow. Antigen-presenting cells (e.g., Langerhans’ cells)
are either negative or show weak and/or restricted areas
of reactivity (e.g., interdigitating reticulum cells). Resting
microglia in the normal white matter of the cerebrum and
microglia in areas of infarction react with the antibody.
Peripheral blood monocytes are also positive, with a
granular staining pattern. The antibody reacts with
myeloid precursors and peripheral blood granulocytes. It
also reacts with the population known as “plasmacytoid T
cells” present in many reactive lymph nodes and believed
CD68⎯tonsil.
to be of monocyte/macrophage origin. The antibody
stains cases of chronic and acute myeloid leukemia, giving
strong granular staining of the cytoplasm of many
cells and also reacts with rare cases of true histiocytic
neoplasia. The positive staining of normal and neoplastic
mast cells is seen with the antibody as well as staining
of a variable number of cells in malignant melanomas.
Neoplasms of lymphoid origin are usually negative,
although some B cell neoplasms, most frequently small
lymphocytic lymphomas and hairy cell leukemias, show
weak staining of the cytoplasm, usually in the form of a
few scattered granules.
anticentriole antibody
An antibody that may occur in serum specific for the
mitotic spindle apparatus (MSA). These antibodies are
rarely found in the sera of subjects developing connective
tissue diseases such as scleroderma.
Anticentromere antibody.
anticentromere antibody
Antibody against the centromere antigens CENP-A
and CENP-B present in approximately 95% of CREST
syndrome patients. They are much less frequent in cases
of diffuse scleroderma and are considered significant
diagnostic markers for scleroderma with limited skin
involvement and also have prognostic significance.
Indirect immunofluorescence and immunoblotting are
the suggested methods for assay. Twelve percent of primary
biliary cirrhosis patients, half of whom also have
manifestations of systemic sclerosis, have anticentromere
A