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hesus incompatibility 624 rheumatoid arthritis<br />

33<br />

13<br />

hemolytic disease of the newborn in subsequent pregnancies.<br />

This is now prevented by the administration of Rh o(D)<br />

immune globulin to these women within 72 hours of<br />

parturition. Further confusion concerning this system has<br />

arisen from the use of other designations by the Wiener and<br />

Fisher systems. Rh antigens are a group of 7- to 10-kDa,<br />

erythrocyte membrane-bound antigens that are independent<br />

of phosphatides and proteolipids. Antibodies against Rh<br />

antigens do not occur naturally in serum.<br />

rhesus incompatibility<br />

The stimulation of anti-RhD antibodies in an Rh – mother<br />

when challenged by RhD + red cells of her baby (especially<br />

at parturition) that may lead to hemolytic disease of the<br />

newborn. The term also refers to the transfusion of RhD +<br />

blood to an Rh – individual who may form antiD antibodies<br />

against the donor blood, leading to subsequent incompatibility<br />

reactions if given future RhD + blood.<br />

rheumatic<br />

Adjective that describes an inflammatory disease of the<br />

joints, muscles, or connective tissues.<br />

rheumatic fever (RF)<br />

An acute, nonsuppurative, inflammatory disease that is<br />

autoimmune-mediated and occurs mainly in children a few<br />

48<br />

68<br />

100<br />

80<br />

113 152<br />

131 132<br />

Principal Rh Genes and Their Frequencies Among<br />

Caucasians and African Americans<br />

Haplotype Fisher-Race Wiener Caucasian<br />

169<br />

189<br />

225<br />

205<br />

236<br />

256<br />

287 288<br />

267 308<br />

Schematic representation of the suggested molecular structure of Rh polypeptide.<br />

Frequency (%)<br />

African<br />

American<br />

R 1 CDe Rh 1 42 17<br />

R Cde Rh 37 26<br />

R 2 cDE Rh 2 14 11<br />

R 0 cDe Rh o 4 44<br />

r′ Cde rh′ 2 2<br />

rδ cdE Rhδ 1

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