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Untitled - D Ank Unlimited

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eticuloendothelial blockade 620 retroviral oncogene<br />

Bone marrow<br />

Stem cell<br />

Macrophage<br />

reticuloendothelial blockade<br />

The temporary paralysis of the phagocytic ability of cells of<br />

the mononuclear phagocytic system through the injection of<br />

excess amounts of inert particles such as colloidal carbon,<br />

gold, or iron. After the mononuclear phagocytes have<br />

expended their entire phagocytic capabilities by taking up<br />

these inert particles, they can no longer phagocytize administered<br />

microorganisms or other substances that would<br />

normally be phagocytized.<br />

reticuloendothelial system (RES)<br />

A former term for the mononuclear phagocyte system<br />

that includes Kupffer’s cells lining the sinusoids of the<br />

liver and macrophages of the spleen and lymph nodes.<br />

Aschoff introduced the term to describe cells that could<br />

take up and retain vital dyes and particles injected into<br />

the body. In addition to macrophages, less active phagocytic<br />

cells such as fibroblasts and endothelial cells were<br />

included in the original definition. The principal function<br />

of the mononuclear phagocyte system is removal of<br />

unwelcome particles from the blood. RES activity may<br />

be measured by the elimination rate of radiolabeled molecules<br />

or cells such as albumin or erythrocytes coated<br />

with antibody.<br />

reticulosis<br />

Refer to lymphoma.<br />

reticulum cell<br />

Refer to reticular cell.<br />

Blood Tissue<br />

Monocyte<br />

Microglia<br />

Osteoclast<br />

Macrophage<br />

(spleen,<br />

lung, etc.)<br />

Endothelial<br />

cells<br />

Reticuloendothelial system (RES).<br />

Dendritic cell<br />

Langerhans cell<br />

Mesangium<br />

Tissue<br />

mesenchyme<br />

Reticular<br />

cell<br />

reticulum cell sarcoma<br />

Obsolete term for large cell lymphoma.<br />

retina autoantibodies<br />

Autoantibodies found in ANA-negative patients with<br />

cancer-associated retinopathy (CAR) syndrome. These<br />

antibodies are specific for five antigens: retinal S, associated<br />

with ocular inflammation or uveitis; rhodopsin; interphotoreceptor<br />

in retinol-binding protein (IRBP); phosducin;<br />

and CAR autoantigen (recoverin), a 23-kDa protein closely<br />

associated with CAR syndrome. Retina antibodies are<br />

assayed using enzyme immunoassay (EIA), immunoblotting,<br />

and dot blotting; there is no known clinical correlation<br />

for retina autoantibodies.<br />

Retrovir ®<br />

A synthetic nucleoside analog of thymidine in which the<br />

3′ hydroxy group is replaced by an azido group. The FDA<br />

approved it for the treatment of human immunodeficiency<br />

virus (HIV). The mechanism of action includes the conversion<br />

of zidovudine to its active metabolite zidovudine<br />

5′ triphosphate, which inhibits the activity of the HIV<br />

reverse transcriptase by competing for utilization with the<br />

natural substrate and by its incorporation into viral DNA.<br />

Zidovudine is the active component.<br />

retroviral oncogene<br />

The incorporation of a proto-oncogene copy by an integrated<br />

retrovirus into its genome may lead to conversion by<br />

adjacent regulatory sequences of the proto-oncogene into a

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